Mycobacterium abscessus Infections in Cystic Fibrosis Individuals: A Review on Therapeutic Options

被引：21
作者：
Recchia, Deborah [1 ]
Stelitano, Giovanni [1 ]
Stamilla, Alessandro [1 ]
Gutierrez, Damaris L. [1 ]
Degiacomi, Giulia [1 ]
Chiarelli, Laurent R. [1 ]
Pasca, Maria Rosalia [1 ]
机构：
[1] Univ Pavia, Dept Biol & Biotechnol L Spallanzani, I-27100 Pavia, Italy
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2023年 / 24卷 / 05期
关键词：
Mycobacterium abscessus; alternative strategies; nitric oxide; phage therapy; antivirulence compounds; antimicrobial peptides; phytochemicals; drug delivery; GASEOUS NITRIC-OXIDE; ANTIMICROBIAL PEPTIDES; BACTERIOPHAGES; STRATEGIES; PATHOGENS; BACTERIAL; PHAGE; TRIAL;
D O I：
10.3390/ijms24054635
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Mycobacterium abscessus is an opportunistic pathogen that mainly colonizes and infects cystic fibrosis patients' lungs. M. abscessus is naturally resistant to many antibiotics such as rifamycin, tetracyclines and beta-lactams. The current therapeutic regimens are not very effective and are mostly based on repurposed drugs used against Mycobacterium tuberculosis infections. Thus, new approaches and novel strategies are urgently needed. This review aims to provide an overview of the latest ongoing findings to fight M. abscessus infections by analyzing emerging and alternative treatments, novel drug delivery strategies, and innovative molecules.
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