XY sex determination in a cnidarian

被引:3
作者
Chen, Ruoxu [1 ,2 ]
Sanders, Steven M. [3 ,4 ]
Ma, Zhiwei [3 ,4 ]
Paschall, Justin [5 ]
Chang, E. Sally [5 ]
Riscoe, Brooke M. [3 ,4 ]
Schnitzler, Christine E. [6 ]
Baxevanis, Andreas D. [5 ]
Nicotra, Matthew L. [3 ,4 ,7 ]
机构
[1] Tsinghua Univ, Sch Med, Beijing, Peoples R China
[2] Univ Pittsburgh, Sch Med, Pittsburgh, PA USA
[3] Univ Pittsburgh, Starzl Transplantat Inst, Dept Surg, Pittsburgh, PA 15260 USA
[4] Univ Pittsburgh, Ctr Evolutionary Biol & Med, Pittsburgh, PA 15260 USA
[5] Natl Human Genome Res Inst, Computat & Stat Genom Branch, NIH, Bethesda, MD USA
[6] Univ Florida, Whitney Lab Marine Biosci, St Augustine, FL USA
[7] Univ Pittsburgh, Dept Immunol, Pittsburgh, PA 15260 USA
基金
美国国家科学基金会; 美国国家卫生研究院;
关键词
Pseudo-testcross; Pseudoautosomal region; Hydractinia; Sex determination; Linkage map; Depth of coverage; LINKAGE MAPS; SISTER GROUP; EVOLUTION; GENE; FRAMEWORK; ALIGNMENT; SEQUENCE; MASTERS; FORMAT; SLAVES;
D O I
10.1186/s12915-023-01532-2
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
Background Sex determination occurs across animal species, but most of our knowledge about its mechanisms comes from only a handful of bilaterian taxa. This limits our ability to infer the evolutionary history of sex determination within animals. Results In this study, we generated a linkage map of the genome of the colonial cnidarian Hydractinia symbiolongicarpus and used it to demonstrate that this species has an XX/XY sex determination system. We demonstrate that the X and Y chromosomes have pseudoautosomal and non-recombining regions. We then use the linkage map and a method based on the depth of sequencing coverage to identify genes encoded in the non-recombining region and show that many of them have male gonad-specific expression. In addition, we demonstrate that recombination rates are enhanced in the female genome and that the haploid chromosome number in Hydractinia is n = 15. Conclusions These findings establish Hydractinia as a tractable non-bilaterian model system for the study of sex determination and the evolution of sex chromosomes.
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页数:18
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