Serum levels of polychlorinated dibenzo-p-dioxins and polychlorinated dibenzofurans in a sample of Lebanese pregnant women: The role of dietary, anthropometric, and environmental factors

被引：4

作者：

Mahfouz, Yara ^{[1
]}

Harmouche-Karaki, Mireille ^{[1
]}

Matta, Joseph ^{[1
,2
]}

Mahfouz, Maya ^{[1
]}

Salameh, Pascale ^{[3
,4
,5
,6
]}

Younes, Hassan ^{[7
]}

Helou, Khalil ^{[1
]}

Finan, Ramzi ^{[8
,9
,10
]}

Abi-Tayeh, Georges ^{[9
,10
,11
]}

Meslimani, Mohamad ^{[12
]}

Moussa, Ghada ^{[13
]}

Chahrour, Nada ^{[14
]}

Osseiran, Camille ^{[15
]}

Skaiky, Farouk ^{[16
,17
]}

Narbonne, Jean-Francois ^{[18
]}

机构：

[1] St Joseph Univ Beirut, Fac Pharm, Dept Nutr, Med Sci Campus,Damascus Rd,POB 11-5076, Riad Solh Beirut 11072180, Lebanon

[2] Ind Res Inst, Lebanese Univ Campus, Hadath Baabda, Lebanon

[3] Lebanese Univ, Fac Pharm, Clin & Epidemiol Res Lab, Hadath, Lebanon

[4] Lebanese Amer Univ, Sch Med, Byblos, Lebanon

[5] Inst Natl Sante Publ Epidemiol Clin & Toxicol Lib, Beirut, Lebanon

[6] Univ Nicosia Med Sch, Dept Primary Care & Populat Hlth, CY-2417 Nicosia, Cyprus

[7] UniLaSalle Univ, 19 Pierre Waguet St, F-60026 Beauvais, France

[8] Lebanese Soc Obstet & Gynecol, Beit El Tabib 3rd Floor, Beirut, Lebanon

[9] St Joseph Univ Beirut, Fac Med, Med Sci Campus,Damascus Rd, Beirut, Lebanon

[10] St Joseph Univ, Beirut Hosp, Hotel Dieu France, Blvd Alfred Naccache,POB 166830, Beirut, Lebanon

[11] Lebanese Fertil Soc, Beirut, Lebanon

[12] Chtoura Hosp, Gen Management, Zahle, Beqaa, Lebanon

[13] Chtoura Hosp, Dept Obstet & Gynecol, Zahle, Beqaa, Lebanon

[14] SRH Univ Hosp, Dept Obstet & Gynecol, Nabatieh, Lebanon

[15] Kassab Hosp, Dept Obstet & Gynecol, Saida, Lebanon

[16] Al Karim Med Labs, Dept Mol Biol, Gen Management, Saida, Lebanon

[17] Lebanese Univ, Fac Publ Hlth, Saida, Lebanon

[18] Univ Bordeaux, Bordeaux, France

来源：

ENVIRONMENTAL RESEARCH | 2023年 / 216卷

关键词：

Human biomonitoring; Persistent organic pollutants; Dietary exposure; Serum; Dioxins; Exposure predictors; PERSISTENT ORGANIC POLLUTANTS; BIPHENYLS PCBS; ADIPOSE-TISSUE; BREAST-MILK; HALF-LIVES; HUMAN EXPOSURE; BLOOD-LEVELS; FISH; PCDD/FS; HEALTH;

D O I：

10.1016/j.envres.2022.114647

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Polychlorinated dibenzo-p-dioxins (PCDDs) and polychlorinated dibenzofurans (PCDFs) are unintentionally produced, toxic environmental chemicals that persist for long years and bioaccumulate along the food chain, contaminating humans through diet. A particularly critical population subgroup is pregnant women given the adverse health effects on fetuses and newborns. Several anthropogenic sources of exposure to PCDD/Fs exist in Lebanon. Therefore, the aim of the present cross-sectional study is to measure the levels of PCDD/Fs in a sample of pregnant women in Lebanon and to explore potential associated factors. In this study, we measured serum concentrations of seven dioxins and ten furans, among 423 pregnant women recruited at delivery, using gas chromatography MS/MS. Among 269 participants, maternal sociodemographic information was collected including vicinity to landfills, incineration, pesticide use, industrial activity, and smoking. Anthropometric data were registered regarding pre-pregnancy body mass index (BMI), pre-pregnancy weight loss from restrictive diet, and gestational weight gain. Intake of major food groups generally related to PCDD/Fs was reported (fish, red meat, poultry, and dairy). Bivariate and multivariate analyses were performed to identify associations. PCDD/Fs were detected in 0 to 56.1% of the sample. Geometric mean concentrations were 75.5 (2.35) pg/g lipid and 2.25 (1.39) TEQ2005 pg/g lipid for total dioxins, and 2.66 (1.76) pg/g lipid and 0.34 (1.78) TEQ2005 pg/g lipid for total furans. Levels were relatively lower than levels previously observed in France, Germany, Mexico, Ghana, and Japan. Red meat consumption was the most consistently associated factor with a 2.38-2.57 fold increase in PCDD/F levels. Pre-pregnancy weight loss showed inverse associations with PCDD/F congeners. Vicinity to illegal incineration was also associated with a 2.32-2.43 fold increase in PCDD/F levels. In conclusion, results showed the importance of dietary, anthropometric, and environmental factors in the present sample's exposure to PCDD/Fs, in a region that contains anthropogenic sources of contamination.

引用

页数：12

共 109 条

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