Pupil-engineered coherent anti-Stokes Raman scattering spectroscopy

被引：0

作者：

Fukutake, Naoki ^{[1
]}

Ito, Terumasa ^{[2
]}

Kanno, Kozue ^{[1
]}

Toda, Shogo ^{[1
]}

Misawa, Kazuhiko ^{[2
]}

机构：

[1] Nikon Inc, 471 Nagaodai Cho,Sakae Ku, Yokohama, Kanagawa 2448533, Japan

[2] Tokyo Univ Agr & Technol, Dept Biomed Engn, 2-24-16 Naka Cho, Koganei, Tokyo 1848588, Japan

来源：

OPTICS COMMUNICATIONS | 2024年 / 552卷

关键词：

CARS; Pupil engineering; Spectroscopy; Signal -to -background ratio; Nonlinear optics; Pulse shaping; MICROSCOPY; LASER; CARS;

D O I：

10.1016/j.optcom.2023.130076

中图分类号：

O43 [光学];

学科分类号：

070207 ; 0803 ;

摘要：

Coherent anti-Stokes Raman scattering (CARS) spectroscopy suffers from non-resonant background (NB) that is several orders of magnitude stronger than CARS signals. NB occupies the camera sensor dynamic range and hampers quantitative detection of weak Raman signals at low molecular concentrations. Here, we propose a novel technique to reduce NB for heterodyne CARS spectroscopy, by independently controlling the parities of the amplitude point spread functions of CARS and NB. We realize the parity control by applying the pupil engineering of the excitation and detection optical systems. A proof-of-concept experiment shows that the signal-to -background ratio (SBR) of the CARS signal to the NB can be improved as designed.

引用

页数：5

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