Mpox outbreak in the Netherlands, 2022: public health response, characteristics of the first 1,000 cases and protection of the first-generation smallpox vaccine

被引：31

作者：

van Ewijk, Catharina E. ^{[1
,2
]}

Miura, Fuminari ^{[1
,2
,3
]}

van Rijckevorsel, Gini ^{[1
,4
]}

de Vries, Henry J. C. ^{[4
,5
,6
,7
,8
]}

Welkers, Matthijs R. A. ^{[4
,9
]}

van den Berg, Oda E. ^{[1
]}

Friesema, Ingrid H. M. ^{[1
]}

van den Berg, Patrick R. ^{[1
]}

Dalhuisen, Thomas ^{[1
]}

Wallinga, Jacco ^{[1
,10
]}

Brandwagt, Diederik ^{[1
]}

van Cleef, Brigitte A. G. L. ^{[1
,4
]}

Vennema, Harry ^{[1
]}

Voordouw, Bettie ^{[1
]}

Koopmans, Marion ^{[11
]}

van der Eijk, Annemiek A. ^{[11
]}

Swaan, Corien M. ^{[1
]}

te Wierik, Margreet J. M. ^{[1
]}

Leenstra, Tjalling ^{[1
]}

de Coul, Eline Op ^{[1
]}

Franz, Eelco ^{[1
]}

Dutch Mpox Response Team, the Dutch Mpox Response ^{[1
,2
,3
,4
,5
,6
,7
,8
,9
,10
,11
]}

机构：

[1] Natl Inst Publ Hlth & Environm RIVM, Ctr Infect Dis Control, Bilthoven, Netherlands

[2] European Ctr Dis Prevent & Control ECDC, European Programme Intervent Epidemiol Training EP, Solna, Sweden

[3] Ehime Univ, Ctr Marine Environm Studies, Matsuyama, Japan

[4] Publ Hlth Serv Amsterdam, Dept Infect Dis, Amsterdam, Netherlands

[5] Univ Amsterdam, Dept Dermatol, Amsterdam UMC locat, Amsterdam, Netherlands

[6] Amsterdam Inst Infect & Immunol, Infect Dis, Amsterdam, Netherlands

[7] Publ Hlth Serv Amsterdam, Ctr Sexual Hlth, Dept Infect Dis, Amsterdam, Netherlands

[8] Amsterdam Inst Global Hlth & Dev, Amsterdam, Netherlands

[9] Univ Amsterdam, Dept Med Microbiol & Infect Prevent, Amsterdam UMC locat AMC, Amsterdam, Netherlands

[10] Leiden Univ, Dept Biomed Data Sci, Med Ctr, Leiden, Netherlands

[11] Erasmus MC, Dept Virosci, Rotterdam, Netherlands

来源：

EUROSURVEILLANCE | 2023年 / 28卷 / 12期

关键词：

MONKEYPOX;

D O I：

10.2807/1560-7917.ES.2023.28.12.2200772

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

In early May 2022, a global outbreak of mpox started among persons without travel history to regions known to be enzootic for monkeypox virus (MPXV). On 8 August 2022, the Netherlands reported its 1,000th mpox case, representing a cumulative incidence of 55 per million population, one of the highest cumulative incidences worldwide. We describe characteristics of the first 1,000 mpox cases in the Netherlands, reported between 20 May and 8 August 2022, within the context of the public health response. These cases were pre-dominantly men who have sex with men aged 31-45 years. The vast majority of infections were acquired through sexual contact with casual partners in pri-vate or recreational settings including LGBTQIA+ ven-ues in the Netherlands. This indicates that, although some larger upsurges occurred from point-source and/or travel-related events, the outbreak was mainly characterised by sustained transmission within the Netherlands. In addition, we estimated the protective effect of first-generation smallpox vaccine against moderate/severe mpox and found a vaccine effective-ness of 58% (95% CI: 17-78%), suggesting moderate protection against moderate/severe mpox symptoms on top of any possible protection by this vaccine against MPXV infection and disease. Communication with and supporting the at-risk population in following mitigation measures remains essential.

引用

页数：15

共 33 条

[11]

Dutch National Institute of Public Health and the Evironment (RIVM), SIGN INF

[12]

ECDC, 2022, FACTSH HLTH PROF MPO

[13]

European Center for Disease Prevention and Control (ECDC) Risk Assessment, 2022, RISK ASS MONK MULT O

[14]

European Centre for Disease Prevention and Control (ECDC)/ World Health Organisation Regional Office for Europe (WHO/Europe), 2022, JOINT ECDC WHO REG O

[15]

Fenner F., 1988, Smallpox and its eradication Internet

[16]

JEZEK Z, 1988, B WORLD HEALTH ORGAN, V66, P465

[17] Real-time PCR assays for the specific detection of monkeypox virus West African and Congo Basin strain DNA [J].

Li, Yu ;

Zhao, Hui ;

Wilkins, Kimberly ;

Hughes, Christine ;

Damon, Inger K. .

JOURNAL OF VIROLOGICAL METHODS, 2010, 169 (01) :223-227

[18] Species-specific differentiation of variola, monkeypox, and varicella-zoster viruses by multiplex real-time PCR assay [J].

Maksyutov, Rinat A. ;

Gavrilova, Elena V. ;

Shchelkunov, Sergei N. .

JOURNAL OF VIROLOGICAL METHODS, 2016, 236 :215-220

[19]

Mathieu E, Mpox (monkeypox

[20] Phase 3 Efficacy Trial of Modified Vaccinia Ankara as a Vaccine against Smallpox [J].

Pittman, Phillip R. ;

Hahn, Matthew ;

Lee, HeeChoon S. ;

Koca, Craig ;

Samy, Nathaly ;

Schmidt, Darja ;

Hornung, Joachim ;

Weidenthaler, Heinz ;

Heery, Christopher R. ;

Meyer, Thomas P. H. ;

Silbernagl, Guenter ;

Maclennan, Jane ;

Chaplin, Paul .

NEW ENGLAND JOURNAL OF MEDICINE, 2019, 381 (20) :1897-1908

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