Ophthalmoplegia associated with anti-GQ1b antibodies: case report and review

被引：3

作者：

Yvon, Camille ^{[1
]}

Nee, Dominic ^{[2
]}

Chan, Dennis ^{[2
]}

Malhotra, Raman ^{[1
]}

机构：

[1] Queen Victoria Hosp NHS Trust, Corneoplast Unit, E Grinstead, England

[2] Brighton & Sussex Univ Hosp NHS Trust, Neurol Dept, Brighton, E Sussex, England

来源：

ORBIT-THE INTERNATIONAL JOURNAL ON ORBITAL DISORDERS-OCULOPLASTIC AND LACRIMAL SURGERY | 2023年 / 42卷 / 02期

关键词：

Acute ophthalmoparesis without ataxia; GQ1b ganglioside; Guillain-Barre syndrome; ophthalmoplegia; ptosis; GUILLAIN-BARRE-SYNDROME; MILLER FISHER SYNDROME; IGG ANTIBODY; CAMPYLOBACTER-JEJUNI; GM1;

D O I：

10.1080/01676830.2021.1974495

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

A 60-year-old man with longstanding bilateral asymmetrical ptosis presented with a partial third nerve palsy. His diplopia improved following an ice pack test. He did not report any symptoms related to the coronavirus disease 2019 (COVID-19), and nasopharyngeal swab was negative. Initial head imaging and blood work-up were normal except for a high titer of anti-GQ1b antibodies. The patient was subsequently diagnosed with acute ophthalmoparesis without ataxia which is part of the anti-GQ1b antibody syndrome spectrum. He made a spontaneous recovery over the following months without the need for immunotherapy. Clinical features, pathophysiology and a review of the literature are discussed herein. It is important to consider anti-GQ1b antibody syndrome in patients with symptoms of diplopia, ptosis or suspected ocular myasthenia.

引用

页码：192 / 195

页数：4

共 21 条

[1] Miller Fisher Syndrome Mimicking Ocular Myasthenia Gravis [J].

Anthony, Scott A. ;

Thurtell, Matthew J. ;

Leigh, R. John .

OPTOMETRY AND VISION SCIENCE, 2012, 89 (12) :E118-E123

[2] The Ice Pack Test in the Differential Diagnosis of Myasthenic Diplopia [J].

Chatzistefanou, Klio I. ;

Kouris, Tassos ;

Iliakis, Evangelos ;

Piaditis, Georgios ;

Tagaris, Georgios ;

Katsikeris, Nikolaos ;

Kaltsas, Grigorios ;

Apostolopoulos, Michael .

OPHTHALMOLOGY, 2009, 116 (11) :2236-2243

[3] Ganglioside composition of the human cranial nerves, with special reference to pathophysiology of Miller Fisher syndrome [J].

Chiba, A ;

Kusunoki, S ;

Obata, H ;

Machinami, R ;

Kanazawa, I .

BRAIN RESEARCH, 1997, 745 (1-2) :32-36

[4] SERUM ANTI-GQ(1B) IGG ANTIBODY IS ASSOCIATED WITH OPHTHALMOPLEGIA IN MILLER FISHER SYNDROME AND GUILLAIN-BARRE-SYNDROME - CLINICAL AND IMMUNOHISTOCHEMICAL STUDIES [J].

CHIBA, A ;

KUSUNOKI, S ;

OBATA, H ;

MACHINAMI, R ;

KANAZAWA, I .

NEUROLOGY, 1993, 43 (10) :1911-1917

[5] Guillain-Barre syndrome and COVID-19: an observational multicentre study from two Italian hotspot regions [J].

Filosto, Massimiliano ;

Piccinelli, Stefano Cotti ;

Gazzina, Stefano ;

Foresti, Camillo ;

Frigeni, Barbara ;

Servalli, Maria Cristina ;

Sessa, Maria ;

Cosentino, Giuseppe ;

Marchioni, Enrico ;

Ravaglia, Sabrina ;

Briani, Chiara ;

Castellani, Francesca ;

Zara, Gabriella ;

Bianchi, Francesca ;

Del Carro, Ubaldo ;

Fazio, Raffaella ;

Filippi, Massimo ;

Magni, Eugenio ;

Natalini, Giuseppe ;

Palmerini, Francesco ;

Perotti, Anna Maria ;

Bellomo, Andrea ;

Osio, Maurizio ;

Scopelliti, Giuseppe ;

Carpo, Marinella ;

Rasera, Andrea ;

Squintani, Giovanna ;

Doneddu, Pietro Emiliano ;

Bertasi, Valeria ;

Cotelli, Maria Sofia ;

Bertolasi, Laura ;

Fabrizi, Gian Maria ;

Ferrari, Sergio ;

Ranieri, Federico ;

Caprioli, Francesca ;

Grappa, Elena ;

Broglio, Laura ;

De Maria, Giovanni ;

Leggio, Ugo ;

Poli, Loris ;

Rasulo, Frank ;

Latronico, Nicola ;

Nobile-Orazio, Eduardo ;

Padovani, Alessandro ;

Uncini, Antonino .

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 2021, 92 (07) :751-756

[6] Antibodies to gangliosides and galactocerebroside in patients with Guillain-Barre syndrome with preceding Campylobacter jejuni and other identified infections [J].

Hao, Q ;

Saida, T ;

Kuroki, S ;

Nishimura, M ;

Nukina, M ;

Obayashi, H ;

Saida, K .

JOURNAL OF NEUROIMMUNOLOGY, 1998, 81 (1-2) :116-126

[7] Corticosteroids for Guillain-Barre syndrome [J].

Hughes, Richard A. C. ;

Brassington, Ruth ;

Gunn, Angela A. ;

van Doorn, Pieter A. .

COCHRANE DATABASE OF SYSTEMATIC REVIEWS, 2016, (10)

[8] Intravenous immunoglobulin for Guillain-Barre syndrome [J].

Hughes, Richard A. C. ;

Swan, Anthony V. ;

van Doorn, Pieter A. .

COCHRANE DATABASE OF SYSTEMATIC REVIEWS, 2012, (07)

[9] The spectrum of antecedent infections in Guillain-Barre syndrome -: A case-control study [J].

Jacobs, BC ;

Rothbarth, PH ;

van der Meché, FGA ;

Herbrink, P ;

Schmitz, PIM ;

de Klerk, MA ;

van Doorn, PA .

NEUROLOGY, 1998, 51 (04) :1110-1115

[10] Recurrent Guillain-Barre syndrome [J].

Kuitwaard, K. ;

van Koningsveld, R. ;

Ruts, L. ;

Jacobs, B. C. ;

van Doorn, P. A. .

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 2009, 80 (01) :56-59

← 1 2 3 →