The association between the estimated glomerular filtration rate and cognitive impairment: the Suita Study

被引：10

作者：

Arafa, Ahmed ^{[1
,2
]}

Kawachi, Haruna ^{[1
,3
]}

Matsumoto, Chisa ^{[1
,4
]}

Teramoto, Masayuki ^{[1
]}

Yasui, Yuka ^{[1
,5
]}

Kato, Yuka ^{[1
,6
]}

Matsuo, Miki ^{[7
]}

Nakao, Yoko M. ^{[1
,8
]}

Kashima, Rena ^{[1
]}

Kokubo, Yoshihiro ^{[1
]}

机构：

[1] Natl Cerebral & Cardiovasc Ctr, Dept Prevent Cardiol, Suita, Osaka, Japan

[2] Beni Suef Univ, Fac Med, Dept Publ Hlth, Bani Suwayf, Egypt

[3] Osaka Univ, Grad Sch Med, Dept Environm Med & Populat Sci, Suita, Osaka 5650871, Japan

[4] Tokyo Med Univ Hosp, Ctr Hlth Surveillance & Prevent Med, Dept Cardiol, Tokyo, Japan

[5] Doshisha Womens Coll Liberal Arts, Grad Sch Human Life & Sci, Kyoto, Japan

[6] Osaka Univ, Grad Sch Med, Div Hlth Sci, Suita 5650871, Japan

[7] Natl Cerebral & Cardiovasc Ctr, Dept Hypertens & Nephrol, Suita, Japan

[8] Kyoto Univ, Grad Sch Med & Publ Hlth, Dept Pharmacoepidemiol, Kyoto, Japan

来源：

HYPERTENSION RESEARCH | 2024年 / 47卷 / 03期

关键词：

Cognitive impairment; Estimated glomerular filtration rate; Chronic kidney disease; Japan; MENTAL-STATE-EXAMINATION; CHRONIC KIDNEY-DISEASE; DEMENTIA; ONSET; RISK;

D O I：

10.1038/s41440-023-01476-8

中图分类号：

R6 [外科学];

学科分类号：

1002 ; 100210 ;

摘要：

This cross-sectional study investigated the association between the estimated glomerular filtration rate (eGFR), a measure of chronic kidney disease (CKD), and cognitive impairment. We used data from 6215 Japanese individuals registered in the Suita Study. Cognitive impairment was defined as a Mini-Mental State Examination (MMSE) score of <= 26. Logistic regression was used to calculate odds ratios (ORs) and 95% confidence intervals (95% CIs) of cognitive impairment for eGFR 45-59.9 and < 45 mL/min/1.73 m(2) (mild and moderate-to-severe eGFR reductions) compared to eGFR >= 60 mL/min/1.73 m(2) (normal eGFR). The results showed that both mild and moderate-to-severe eGFR reductions were associated with cognitive impairment: ORs (95% CIs) = 1.49 (1.22-1.83) and 2.35 (1.69-3.26), respectively (p-trend < 0.001). Each increment of eGFR by 10 mL/min/1.73m(2) was associated with 4.8% lower odds of cognitive impairment. In conclusion, eGFR reduction was associated with cognitive impairment. Managing CKD is essential for preventing cognitive impairment.

引用

页码：672 / 676

页数：5

共 20 条

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