Cohort profile: rationale and methods of UK Biobank repeat imaging study eye measures to study dementia

被引:8
作者
Foster, Paul J. [1 ]
Atan, Denize [2 ]
Khawaja, Anthony [3 ,4 ]
Lotery, Andrew [5 ]
MacGillivray, Tom [6 ]
Owen, Christopher G. [7 ]
Patel, Praveen J. [8 ]
Petzold, Axel [9 ,10 ,11 ,12 ,13 ]
Rudnicka, Alicja [7 ]
Sun, Zihan [14 ]
Sheard, Simon [15 ]
Allen, Naomi [15 ,16 ]
机构
[1] Moorfields Eye Hosp NHS Fdn Trust, NIHR Moorfields Biomed Res Ctr, London, England
[2] Univ Bristol, Med Sch, Bristol, Avon, England
[3] Moorfields Eye Hosp NHS Fdn Trust, NIHR Biomed Res Ctr, London, England
[4] UCL Inst Ophthalmol, London, England
[5] Univ Southampton, Fac Med, Southampton, Hants, England
[6] Queens Med Res Inst, Clin Res Imaging Ctr, Edinburgh, Midlothian, Scotland
[7] Univ London, Populat Hlth Res Inst, St Georges Med Sch, London, England
[8] Moorfields Eye Hosp NHS Fdn Trust, NIHR Biomed Res Ctr, London, England
[9] UCL, Moorfields Eye Hosp, Dept Mol Neurosci, London, England
[10] UCL, Queen Sq Inst Neurol, Natl Hosp Neurol & Neurosurg, London, England
[11] Amsterdam UMC, Dept Neurol, Amsterdam, Netherlands
[12] Amsterdam UMC, Dept Ophthalmol, Amsterdam, Netherlands
[13] Amsterdam UMC, Expertise Ctr Neuroophthalmol, Amsterdam, Netherlands
[14] UCL, Inst Ophthalmol, London, England
[15] UK Biobank, Stockport, Lancs, England
[16] Univ Oxford, Nuffield Dept Populat Hlth, Oxford, England
基金
英国医学研究理事会; 英国惠康基金;
关键词
ophthalmology; epidemiology; dementia; ALZHEIMERS-DISEASE; RISK-FACTORS; ASSOCIATIONS; RECOMMENDATIONS; EPIDEMIOLOGY; PRESSURE;
D O I
10.1136/bmjopen-2022-069258
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
PurposeThe retina provides biomarkers of neuronal and vascular health that offer promising insights into cognitive ageing, mild cognitive impairment and dementia. This article described the rationale and methodology of eye and vision assessments with the aim of supporting the study of dementia in the UK Biobank Repeat Imaging study. ParticipantsUK Biobank is a large-scale, multicentre, prospective cohort containing in-depth genetic, lifestyle, environmental and health information from half a million participants aged 40-69 enrolled in 2006-2010 across the UK. A subset (up to 60 000 participants) of the cohort will be invited to the UK Biobank Repeat Imaging Study to collect repeated brain, cardiac and abdominal MRI scans, whole-body dual-energy X-ray absorptiometry, carotid ultrasound, as well as retinal optical coherence tomography (OCT) and colour fundus photographs. Findings to dateUK Biobank has helped make significant advances in understanding risk factors for many common diseases, including for dementia and cognitive decline. Ophthalmic genetic and epidemiology studies have also benefited from the unparalleled combination of very large numbers of participants, deep phenotyping and longitudinal follow-up of the cohort, with comprehensive health data linkage to disease outcomes. In addition, we have used UK Biobank data to describe the relationship between retinal structures, cognitive function and brain MRI-derived phenotypes. Future plansThe collection of eye-related data (eg, OCT), as part of the UK Biobank Repeat Imaging study, will take place in 2022-2028. The depth and breadth and longitudinal nature of this dataset, coupled with its open-access policy, will create a major new resource for dementia diagnostic discovery and to better understand its association with comorbid diseases. In addition, the broad and diverse data available in this study will support research into ophthalmic diseases and various other health outcomes beyond dementia.
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页数:10
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