A consortium of three-bacteria isolated from human feces inhibits formation of atherosclerotic deposits and lowers lipid levels in a mouse model

被引：8

作者：

Jie, Zhuye ^{[1
,2
,3
]}

Zhu, Qian ^{[4
,5
,6
]}

Zou, Yuanqiang ^{[1
,3
,7
,8
]}

Wu, Qili ^{[4
,5
,6
]}

Qin, Min ^{[4
,5
,6
]}

He, Dongdong ^{[1
]}

Lin, Xiaoqian ^{[1
]}

Tong, Xin ^{[1
]}

Zhang, Jiahao ^{[1
]}

Jie, Zhu ^{[1
]}

Luo, Wenwei ^{[4
,5
]}

Xiao, Xiao ^{[4
,5
]}

Chen, Shiyu ^{[4
,5
]}

Wu, Yonglin ^{[4
,5
]}

Guo, Gongjie ^{[4
,5
,6
]}

Zheng, Shufen ^{[4
,5
]}

Li, Yong ^{[9
]}

Lai, Weihua ^{[4
]}

Yang, Huanming ^{[1
,10
]}

Wang, Jian ^{[1
,10
]}

Xiao, Liang ^{[1
,7
,8
]}

Chen, Jiyan ^{[5
]}

Zhang, Tao ^{[1
,2
,3
]}

Kristiansen, Karsten ^{[1
,3
,7
]}

Jia, Huijue ^{[1
,2
]}

Zhong, Shilong ^{[4
,5
,6
]}

机构：

[1] BGI Shenzhen, Shenzhen, Peoples R China

[2] BGI Shenzhen, Shenzhen Key Lab Human Commensal Microorganisms &, Shenzhen, Peoples R China

[3] Univ Copenhagen, Dept Biol, Lab Genom & Mol Biomed, Univ Pk 13, DK-2100 Copenhagen, Denmark

[4] Southern Med Univ, Guangdong Prov Peoples Hosp, Guangdong Acad Med Sci, Dept Pharm, Guangzhou 510080, Guangdong, Peoples R China

[5] Southern Med Univ, Guangdong Prov Peoples Hosp, Guangdong Cardiovasc Inst, Guangdong Acad Med Sci,Guangdong Prov Key Lab Coro, Guangzhou 510080, Guangdong, Peoples R China

[6] South China Univ Technol, Sch Med, Guangzhou 510006, Peoples R China

[7] BGI Shenzhen, Qingdao Europe Adv Inst Life Sci, Qingdao 266555, Peoples R China

[8] BGI Shenzhen, Shenzhen Engn Lab Detect & Intervent Human Intesti, Shenzhen, Peoples R China

[9] Southern Med Univ Guangzhou, Guangdong Prov Peoples Hosp, Guangdong Acad Med Sci, Dept Surg, Guangzhou 510080, Guangdong, Peoples R China

[10] James D Watson Inst Genome Sci, Hangzhou, Peoples R China

来源：

ISCIENCE | 2023年 / 26卷 / 06期

基金：

中国国家自然科学基金;

关键词：

BETA-METHYLBUTYRATE HMB; GUT MICROBIOTA; CARDIOVASCULAR-DISEASE; BILE-ACIDS; AEROCOCCUS-VIRIDANS; METABOLISM; BACTERIA; OBESITY; GENES; PHOSPHATIDYLCHOLINE;

D O I：

10.1016/j.isci.2023.106960

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

By a survey of metagenome-wide association studies (MWAS), we found a robust depletion of Bacteroides cellulosilyticus, Faecalibacterium prausnitzii, and Roseburia intestinalis in individuals with atherosclerotic cardiovascular disease (ACVD). From an established collection of bacteria isolated from healthy Chinese individuals, we selected B. cellulosilyticus, R. intestinalis, and Faecalibacterium longum, a bacterium related to F. prausnitzii, and tested the effects of these bacteria in an Apoe(/-) atherosclerosis mouse model. We show that administration of these three bacterial species to Apoe(-/-) mice robustly improves cardiac function, reduces plasma lipid levels, and attenuates the formation of atherosclerotic plaques. Comprehensive analysis of gut microbiota, plasma metabolome, and liver transcriptome revealed that the beneficial effects are associated with a modulation of the gut microbiota linked to a 7 alpha-dehydroxylation-lithocholic acid (LCA)-farnesoid X receptor (FXR) pathway. Our study provides insights into transcriptional and metabolic impact whereby specific bacteria may hold promises for prevention/treatment of ACVD.

引用

页数：22

共 84 条

[1]

Anderson M. J., 2014, Wiley StatsRef: Statistics Reference Online, P1, DOI [10.1002/9781118445112.stat07841, DOI 10.1002/9781118445112.STAT07841]

[2] Using genetic markers to orient the edges in quantitative trait networks: The NEO software [J].

Aten, Jason E. ;

Fuller, Tova F. ;

Lusis, Aldons J. ;

Horvath, Steve .

BMC SYSTEMS BIOLOGY, 2008, 2

[3] Integrating taxonomic, functional, and strain-level profiling of diverse microbial communities with bioBakery 3 [J].

Beghini, Francesco ;

McIver, Lauren J. ;

Blanco-Miguez, Aitor ;

Dubois, Leonard ;

Asnicar, Francesco ;

Maharjan, Sagun ;

Mailyan, Ana ;

Manghi, Paolo ;

Scholz, Matthias ;

Thomas, Andrew Maltez ;

Valles-Colomer, Mireia ;

Weingart, George ;

Zhang, Yancong ;

Zolfo, Moreno ;

Huttenhower, Curtis ;

Franzosa, Eric A. ;

Segata, Nicola .

ELIFE, 2021, 10

[4] Gut microbiota impact on the peripheral immune response in non-alcoholic fatty liver disease related hepatocellular carcinoma [J].

Behary, Jason ;

Amorim, Nadia ;

Jiang, Xiao-Tao ;

Raposo, Anita ;

Gong, Lan ;

McGovern, Emily ;

Ibrahim, Ragy ;

Chu, Francis ;

Stephens, Carlie ;

Jebeili, Hazem ;

Fragomeli, Vincenzo ;

Koay, Yen Chin ;

Jackson, Miriam ;

O'Sullivan, John ;

Weltman, Martin ;

McCaughan, Geoffrey ;

El-Omar, Emad ;

Zekry, Amany .

NATURE COMMUNICATIONS, 2021, 12 (01)

[5] Metabolic products of the intestinal microbiome and extremes of atherosclerosis [J].

Bogiatzi, Chrysi ;

Gloor, Gregory ;

Allen-Vercoe, Emma ;

Reid, Gregor ;

Wong, Ruth G. ;

Urquhart, Bradley L. ;

Dinculescu, Vincent ;

Ruetz, Kelsey N. ;

Velenosi, Thomas J. ;

Pignanelli, Michael ;

Spence, J. David .

ATHEROSCLEROSIS, 2018, 273 :91-97

[6] Specific gut microbiota features and metabolic markers in postmenopausal women with obesity [J].

Brahe, L. K. ;

Le Chatelier, E. ;

Prifti, E. ;

Pons, N. ;

Kennedy, S. ;

Hansen, T. ;

Pedersen, O. ;

Astrup, A. ;

Ehrlich, S. D. ;

Larsen, L. H. .

NUTRITION & DIABETES, 2015, 5 :e159-e159

[7] Commensal bacteria at the interface of host metabolism and the immune system [J].

Brestoff, Jonathan R. ;

Artis, David .

NATURE IMMUNOLOGY, 2013, 14 (07) :676-684

[8] Precision microbiome reconstitution restores bile acid mediated resistance to Clostridium difficile [J].

Buffie, Charlie G. ;

Bucci, Vanni ;

Stein, Richard R. ;

McKenney, Peter T. ;

Ling, Lilan ;

Gobourne, Asia ;

No, Daniel ;

Liu, Hui ;

Kinnebrew, Melissa ;

Viale, Agnes ;

Littmann, Eric ;

van den Brink, Marcel R. M. ;

Jenq, Robert R. ;

Taur, Ying ;

Sander, Chris ;

Cross, Justin R. ;

Toussaint, Nora C. ;

Xavier, Joao B. ;

Pamer, Eric G. .

NATURE, 2015, 517 (7533) :205-U207

[9] The potential of tailoring the gut microbiome to prevent and treat cardiometabolic disease [J].

Chakaroun, Rima Mohsen ;

Olsson, Lisa M. ;

Backhed, Fredrik .

NATURE REVIEWS CARDIOLOGY, 2023, 20 (04) :217-235

[10]

Chen Fengzhen, 2020, Yichuan, V42, P799, DOI 10.16288/j.yczz.20-080

← 1 2 3 4 5 6 7 8 9 →