Miliary Tuberculosis in a Patient With Ulcerative Colitis Treated With Tofacitinib

被引：1

作者：

Verma, Shruti ^{[1
]}

Singh, Arshdeep ^{[2
]}

Kakkar, Chandan ^{[3
]}

Tripathi, Ashish ^{[2
]}

Midha, Vandana ^{[4
]}

Sood, Ajit ^{[2
]}

机构：

[1] HCA Healthcare Kansas City Program, Dept Internal Med, Kansas City, KS USA

[2] Dayanand Med Coll, Dept Gastroenterol, Ludhiana, Punjab, India

[3] Dayanand Med Coll, Dept Radiol & Radiodiag, Ludhiana, Punjab, India

[4] Dayanand Med Coll, Dept Internal Med, Ludhiana, Punjab, India

来源：

ACG CASE REPORTS JOURNAL | 2023年 / 10卷 / 06期

关键词：

tofacitinib; latent tuberculosis; miliary tuberculosis; inflammatory bowel disease; ulcerative colitis; case report; ASIA-PACIFIC ASSOCIATION; GASTROENTEROLOGY CONSENSUS; INFECTION; ORGANIZATION; CROHNS; RISK;

D O I：

10.14309/crj.0000000000001066

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Immunosuppression with tumor necrosis factor-alpha inhibitors and tofacitinib is a risk factor for reactivation of latent tuberculosis (TB) and the development of active TB. We report a case of miliary TB in a patient on treatment with tofacitinib for active ulcerative colitis. By week 4 of therapy, a clinical response was achieved. Subsequently, although being on treatment, the patient started having fever with night sweats and myalgias. The investigative workup revealed pulmonary miliary TB. Tofacitinib was withdrawn, and antitubercular therapy was initiated. The patient responded, both clinically and radiologically, to the antitubercular therapy. This case report highlights the importance of screening for latent TB in patients receiving tofacitinib.

引用

页数：4

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