The bFGF Can Improve Angiogenesis in Oral Mucosa and Accelerate Wound Healing

被引：5

作者：

Zare, Reza ^{[1
]}

Abdolsamadi, Hamidreza ^{[2
]}

Asl, Sara Soleimani ^{[3
,4
]}

Radi, Shahrbanoo ^{[5
]}

Bahrami, Hossein ^{[6
]}

Jamshidi, Shokoofeh ^{[7
]}

机构：

[1] Mashhad Univ Med Sci, Dent Res Ctr, Mashhad, Iran

[2] Hamadan Univ Med Sci, Dent Res Ctr, Dept Oral Med, Hamadan, Iran

[3] Hamadan Univ Med Sci, Sch Med, Dept Anat, Hamadan, Iran

[4] Hamadan Univ Med Sci, Endometrium & Endometriosis Res Ctr, Hamadan, Iran

[5] Hamedan Univ Med Sci, Dept Oral Med, Hamadan, Iran

[6] Gen Dentist, Private Practice, Hamadan, Iran

[7] Hamadan Univ Med Sci, Sch Dent, Dent Res Ctr, Dept Oral & Maxillofacial Pathol, Hamadan, Iran

来源：

REPORTS OF BIOCHEMISTRY AND MOLECULAR BIOLOGY | 2023年 / 11卷 / 04期

关键词：

bFGF; Healing; Angiogenesis; Wound; Micro Vessel Density; FIBROBLAST-GROWTH-FACTOR; CELL-PROLIFERATION; MIGRATION; REPAIR; ULCERS; SALIVA;

D O I：

暂无

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Background: The role of the basic fibroblast growth factor (bFGF) has well known in the angiogenesis and ulcer healing. In this study, we aimed to evaluate the effects of bFGF on tissue repair in a rat oral mucosal wound.Methods: Musosal wound induced on the lip mucosa of rats and bFGF was injected along the edge of the mucosal defect immediately after surgery. The tissues were collected on days 3, 7 and 14 after the wound induction. The micro vessel density (MVD) and CD34 expression were done by histochemical studies.Results: The bFGF significantly accelerated granulation tissue formation and MVD was increased three days after ulcer induction but decreased 14 days after surgery. The MVD was significantly higher in the bFGF-treated group. The wound area was decreased in all groups time-dependently and a statistically significant difference (p value?) was observed between the bFGF-treated group and untreated group. The wound area was smaller in the bFGF-treated group compared to the untreated group.Conclusions: Our data demonstrated that bFGF can accelerated and facilitated wound healing.

引用

页码：547 / 552

页数：6