Impact of interleukin-6 on T cells in kidney transplant recipients

被引：12

作者：

Chandran, Sindhu ^{[1
]}

Tang, Qizhi ^{[2
]}

机构：

[1] Univ Calif San Francisco, Dept Med, San Francisco, CA 94143 USA

[2] Univ Calif San Francisco, Gladstone UCSF Inst Genome Immunol, Diabet Ctr, Dept Surg, San Francisco, CA USA

来源：

AMERICAN JOURNAL OF TRANSPLANTATION | 2022年 / 22卷

关键词：

clinical research; practice; cytokines; cytokine receptors; immunobiology; immunosuppression; immune modulation; immunosuppressant-fusion proteins and monoclonal antibodies; T cell specific; kidney transplantation; nephrology; lymphocyte biology; differentiation; maturation; rejection; T cell mediated (TCMR); tolerance; clinical; translational research; science; ANTIBODY-MEDIATED REJECTION; HUMAN RENAL-ALLOGRAFTS; GROWTH-FACTOR-BETA; TGF-BETA; RHEUMATOID-ARTHRITIS; RECEPTOR BLOCKADE; EPITHELIAL-CELLS; MIXED CHIMERISM; HELPER-CELLS; TH17; CELLS;

D O I：

10.1111/ajt.17209

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

Interleukin-6 (IL-6), a multifunctional proinflammatory cytokine, plays a key role in T cell activation, survival, and differentiation. Acting as a switch that induces the differentiation of naive T cells into Th17 cells and inhibits their development into regulatory T cells, IL-6 promotes rejection and abrogates tolerance. Therapies that target IL-6 signaling include antibodies to IL-6 and the IL-6 receptor and inhibitors of janus kinases; several of these therapeutics have demonstrated robust clinical efficacy in autoimmune and inflammatory diseases. Clinical trials of IL-6 inhibition in kidney transplantation have focused primarily on its effects on B cells, plasma cells, and HLA antibodies. In this review, we summarize the impact of IL-6 on T cells in experimental models of transplant and describe the effects of IL-6 inhibition on the T cell compartment in kidney transplant recipients.

引用

页码：18 / 27

页数：10

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