Comparative Study Between Silver Nanoparticles Dressing (SilvrSTAT Gel) and Conventional Dressing in Diabetic Foot Ulcer Healing: A Prospective Randomized Study

被引:16
作者
Essa, Mohamed S. [1 ]
Ahmad, Khaled S. [2 ]
Zayed, Mohamed E. [1 ]
Ibrahim, Samia G. [1 ]
机构
[1] Benha Univ, Benha Univ Hosp, Banha, Egypt
[2] Prince Mohammed Bin Abdulaziz Hosp, Riyadh, Saudi Arabia
关键词
foot ulcer; SilvrSTAT Gel; nanoparticles; conventional dressing; healing; PLATELET-RICH PLASMA; ANTIBACTERIAL ACTIVITY; ESCHERICHIA-COLI;
D O I
10.1177/1534734620988217
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
Background We are trying to evaluate silver nanoparticles' effectiveness (SilvrSTAT Gel) in accelerating healing rate of nonischemic diabetic foot ulcers (DFUs). Methods This prospective, double-blind, randomized, controlled study includes 80 patients with nonischemic DFUs classified into 2 groups. Group A was subjected to SilvrSTAT Gel dressing, and group B was subjected to conventional dressing (wet-to-moist dressing with or without povidone-iodine). All cases had minimal debridement before treatment. In both groups, all cases were nonischemic after successful revascularization either by bypass surgery or endovascular therapy. Results The healing rate of the SilvrSTAT group was significantly higher than that of the conventional group. The healing rate per week of the SilvrSTAT group was considerably higher than that of the conventional group (P < .0001). The rate of complete healing for ulcers in group A was achieved in 22 patients (55%) by the 6th week, while 29 (72.5%), 34 (85%), and 36 (90%) patients were healed entirely by the 8th, 10th, and 12th weeks, respectively. In group B: 20 (50%), 27 (67.5%), and 30 (75%) patients were completeley healed by the 8th, 10th, and 12th weeks, respectively. Conclusions SilvrSTATGel is effective in the treatment of DFU.
引用
收藏
页码:48 / 55
页数:8
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