Vagus Nerve Stimulation Attenuates Septic Shock-Induced Cardiac Injury in Rats

被引：1
作者：
Shen, Yuchao [1 ]
Cui, Meixia [1 ]
Cui, Ying [1 ]
机构：
[1] Cangzhou Cent Hosp, Dept Emergency Brain Acad Dist, 16 Xinhua West Rd, Cangzhou 061000, Hebei, Peoples R China
来源：
PHYSIOLOGICAL RESEARCH | 2023年 / 72卷 / 06期
关键词：
Vagus nerve stimulation; Septic shock; Cardiac injury; Inflammatory response; AUTONOMIC REGULATION THERAPY; VAGAL-STIMULATION; HEART-FAILURE; SEPSIS; DEPRESSION; ALPHA; DEATH; TNF;
D O I：
10.33549/physiolres.935136
中图分类号：
Q4 [生理学];
学科分类号：
071003 ;
摘要：
This research aimed to evaluate whether vagus nerve stimulation (VNS) could effectively prevent septic shock-induced cardiac injury in rats and investigate the potential mechanisms. Female Sprague-Dawley rats were divided into the Sham group (sham cecal ligation and puncture [CLP] plus vagal nerve trunk separation), the Vehicle group (CLP plus vagal nerve trunk separation), and the VNS groups (CLP plus vagal nerve trunk separation plus VNS). The left ventricular function was analyzed by echocardiography. Histologic examinations of the cardiac tissues were performed through hematoxylin and eosin staining and TUNEL staining. The Vehicle group had worse cardiac function, higher levels of cardiac injury markers, and enhanced myocardial apoptosis than the Sham group. The rats in the VNS groups had enhanced cardiac function, lower levels of cardiac in septic shock rats were inhibited by the performance of VNS. tissues via the regulation of NF-KB signal.
引用
收藏
页码：731 / 739
页数：9
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