The aberrant glycolysis in kidney proximal tubule: potential therapeutic target for DKD

被引：8
|
作者：
Kanasaki, Keizo [1 ]
机构：
[1] Shimane Univ, Fac Med, Dept Internal Med 1, 89-1 Enya Cho, Izumo 6938501, Japan
来源：
KIDNEY INTERNATIONAL | 2023年 / 104卷 / 06期
基金：
日本学术振兴会;
关键词：
D O I：
10.1016/j.kint.2023.09.019
中图分类号：
R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];
学科分类号：
1002 ; 100201 ;
摘要：
The presence of glycolysis in kidney proximal tubule has been long debated. However, recent reports suggest that aberrant glycolysis is induced in pathologic conditions and may play a critical role in kidney damage. Azushima et al. provided additional evidence that the accumulation of glycolysis-derived lactate could be the clue to understanding the pathogenesis of diabetic kidney disease.
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页码：1056 / 1059
页数：4
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