Association between birth weight/joint exposure to ambient air pollutants and type 2 diabetes: a cohort study in the UK Biobank

被引:0
|
作者
Liu, Xiaojing [1 ,2 ]
Liu, Xiaowen [1 ,2 ]
Jin, Ming [1 ,2 ]
Huang, Ninghao [1 ]
Song, Zimin [1 ]
Li, Nan [1 ,2 ,5 ]
Huang, Tao [1 ,3 ,4 ]
机构
[1] Peking Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, Beijing, Peoples R China
[2] Peking Univ, Inst Reprod & Child Hlth, Key Lab Reprod Hlth, Beijing, Peoples R China
[3] Peking Univ, Key Lab Mol Cardiovasc Sci, Minist Educ, Beijing, Peoples R China
[4] Peking Univ, Inst Artificial Intelligence, Ctr Intelligent Publ Hlth, Beijing, Peoples R China
[5] 38 Xueyuan Rd, Beijing 100191, Peoples R China
关键词
Type; 2; diabetes; birth weight; air pollution score; joint effect; UK biobank; LONG-TERM EXPOSURE; POLLUTION; MELLITUS; HEALTH; RISK; DISORDERS; GROWTH; LIFE; NO2;
D O I
10.1080/09603123.2023.2278634
中图分类号
X [环境科学、安全科学];
学科分类号
08 ; 0830 ;
摘要
Early life events and environmental factors are associated with type 2 diabetes (T2D) development. We assessed the combined effect of birth weight andambient air pollutants, and effect of their interaction on T2D risk. Totally, 6,474 T2D incidents were recorded over an 8.7-year follow-up period. The adjusted hazard ratios (aHRs) with 95% confidence intervals (CIs) were 1.31 (1.26, 1.36) for each kilogram decrease in birth weight, and 1.08 (1.05, 1.11) for each standard deviation increase in air pollution score (APS). Birth weight<3000 g amplified the T2D risk associated with high APS. A combination of the lowest birth weight (<2500 g) and the highest quintile of APS led to over two-fold increase in T2D risk (aHR: 2.17; 95% CI: 1.79-2.64). There was a significant additive interaction between them. In conclusion, ambient air pollutants increase the risk for T2D, particularly in populations with low birth weight.
引用
收藏
页码:2888 / 2898
页数:11
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