Effects of hydroxyapatite-coated porous titanium scaffolds functionalized by exosomes on the regeneration and repair of irregular bone
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作者:
Shao, Hanyu
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China Med Univ, Hosp 1, Dept Plast Surg, Shenyang, Peoples R ChinaChina Med Univ, Hosp 1, Dept Plast Surg, Shenyang, Peoples R China
Shao, Hanyu
[1
]
Zhang, Qiyue
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China Med Univ, Sch & Hosp Stomatol, Liaoning Prov Key Lab Oral Dis, Shenyang, Peoples R ChinaChina Med Univ, Hosp 1, Dept Plast Surg, Shenyang, Peoples R China
Zhang, Qiyue
[2
]
Sun, Mingman
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China Med Univ, Hosp 1, Dept Plast Surg, Shenyang, Peoples R ChinaChina Med Univ, Hosp 1, Dept Plast Surg, Shenyang, Peoples R China
Sun, Mingman
[1
]
Wu, Ming
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China Med Univ, Hosp 1, Dept Plast Surg, Shenyang, Peoples R ChinaChina Med Univ, Hosp 1, Dept Plast Surg, Shenyang, Peoples R China
Wu, Ming
[1
]
Sun, Xu
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China Med Univ, Hosp 1, Dept Plast Surg, Shenyang, Peoples R ChinaChina Med Univ, Hosp 1, Dept Plast Surg, Shenyang, Peoples R China
Sun, Xu
[1
]
Wang, Qiang
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China Med Univ, Sch & Hosp Stomatol, Liaoning Prov Key Lab Oral Dis, Shenyang, Peoples R ChinaChina Med Univ, Hosp 1, Dept Plast Surg, Shenyang, Peoples R China
Wang, Qiang
[2
]
Tong, Shuang
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China Med Univ, Hosp 1, Dept Plast Surg, Shenyang, Peoples R ChinaChina Med Univ, Hosp 1, Dept Plast Surg, Shenyang, Peoples R China
Tong, Shuang
[1
]
机构:
[1] China Med Univ, Hosp 1, Dept Plast Surg, Shenyang, Peoples R China
[2] China Med Univ, Sch & Hosp Stomatol, Liaoning Prov Key Lab Oral Dis, Shenyang, Peoples R China
As a traditional bone implant material, titanium (Ti) and its alloys have the disadvantages of lack of biological activity and susceptibility to stress shielding effect. Adipose stem cells (ADSCs) and exosomes were combined with the scaffold material in the current work to effectively create a hydroxyapatite (HA) coated porous titanium alloy scaffold that can load ADSCs and release exosomes over time. The composite made up for the drawbacks of traditional titanium alloy materials with higher mechanical characteristics and a quicker rate of osseointegration. Exosomes (Exos) are capable of promoting the development of ADSCs in porous titanium alloy scaffolds with HA coating, based on experimental findings from in vitro and in vivo research. Additionally, compared to pure Ti implants, the HA scaffolds loaded with adipose stem cell exosomes demonstrated improved bone regeneration capability and bone integration ability. It offers a theoretical foundation for the combined use of stem cell treatment and bone tissue engineering, as well as a design concept for the creation and use of novel clinical bone defect repair materials.