Prevalence, years lived with disability, and trends in anaemia burden by severity and cause, 1990-2021: findings from the Global Burden of Disease Study 2021

被引：217

作者：

Gardner, William M. ^{[1
]}

Razo, Christian ^{[1
]}

McHugh, Theresa A. ^{[1
]}

Hagins, Hailey ^{[1
]}

Vilchis-Tella, Victor M. ^{[1
]}

Hennessy, Conor ^{[1
,7
]}

Taylor, Heather Jean ^{[1
]}

Perumal, Nandita ^{[1
]}

Fuller, Kia ^{[1
]}

Cercy, Kelly M. ^{[1
]}

Zoeckler, Leo Zucker ^{[1
]}

Chen, Catherine S. ^{[1
]}

Lim, Stephen S. ^{[1
,2
]}

Aali, Amirali ^{[8
]}

Abate, Kalkidan Hassen ^{[12
]}

Abd-Elsalam, Sherief ^{[15
]}

Abdurehman, Ame Mehadi ^{[16
]}

Abebe, Getachew ^{[21
]}

Abidi, Hassan ^{[27
]}

Aboagye, Richard Gyan ^{[29
]}

Abolhassani, Hassan ^{[32
,46
]}

Aboye, Girma Beressa ^{[47
,48
]}

Abtew, Yonas Derso ^{[22
]}

Accrombessi, Manfred Mario Kokou ^{[49
,51
]}

Adane, Denberu Eshetie ^{[52
]}

Adane, Tigist Demssew ^{[53
]}

Addo, Isaac Yeboah ^{[55
,58
]}

Adesina, Miracle Ayomikun ^{[59
,60
]}

Adeyinka, Daniel Adedayo ^{[66
,67
]}

Adnani, Qorinah Estiningtyas Sakilah ^{[68
]}

Afzal, Muhammad Sohail ^{[69
]}

Afzal, Saira ^{[71
,72
]}

Agustina, Rina ^{[73
,74
]}

Ahinkorah, Bright Opoku ^{[75
]}

Ahmad, Aqeel ^{[76
]}

Ahmad, Sajjad ^{[78
]}

Ahmadi, Sepideh ^{[79
]}

Ahmed, Ayman ^{[89
,90
]}

Rashid, Tarik Ahmed ^{[91
]}

Aiman, Wajeeha ^{[92
]}

Ajami, Marjan ^{[80
,93
]}

Akbarialiabad, Hossein ^{[94
]}

Alahdab, Fares ^{[97
]}

Al-Aly, Ziyad ^{[98
,99
]}

Alam, Nazmul ^{[100
]}

Alemayehu, Astawus ^{[101
,102
]}

Alhassan, Robert Kaba ^{[30
]}

Ali, Muhammad Ashar ^{[103
]}

Almustanyir, Sami ^{[104
,105
]}

Al-Raddadi, Rajaa M. ^{[106
]}

机构：

[1] Inst Hlth Metr & Evaluat, Seattle, WA 98195 USA

[2] Univ Washington, Dept Hlth Metr Sci, Sch Med, Seattle, WA USA

[3] Univ Washington, Dept Appl Math, Seattle, WA USA

[4] Univ Washington, Dept Global Hlth, Seattle, WA USA

[5] Univ Washington, Dept Family Med, Seattle, WA USA

[6] Univ Washington, Dept Anesthesiol & Pain Med, Seattle, WA USA

[7] Oregon Hlth & Sci Univ, Ctr Hlth Syst Effectiveness, Portland, OR USA

[8] Mashhad Univ Med Sci, Fac Med, Mashhad, Razavi Khorasan, Iran

[9] Mashhad Univ Med Sci, E Learning Ctr, Mashhad, Razavi Khorasan, Iran

[10] Mashhad Univ Med Sci, Appl Biomed Res Ctr, Mashhad, Razavi Khorasan, Iran

[11] Mashhad Univ Med Sci, Biotechnol Res Ctr, Mashhad, Razavi Khorasan, Iran

[12] Jimma Univ, Dept Nutr & Dietet, Jimma, Ethiopia

[13] Jimma Univ, Dept Publ Hlth, Jimma, Ethiopia

[14] Jimma Univ, Dept Hlth Behav & Soc, Jimma, Ethiopia

[15] Tanta Univ, Trop Med Dept, Tanta, Egypt

[16] Haramaya Univ, Dept Emergency & Crit Care Nursing, Harar, Ethiopia

[17] Haramaya Univ, Dept Hlth Informat, Harar, Ethiopia

[18] Haramaya Univ, Dept Publ Hlth, Harar, Ethiopia

[19] Haramaya Univ, Sch Nursing & Midwifery, Harar, Ethiopia

[20] Haramaya Univ, Dept Med Lab Sci, Harar, Ethiopia

[21] Arba Minch Univ, Dept Med Anat, Arba Minch, Ethiopia

[22] Arba Minch Univ, Dept Biomed Sci, Arba Minch, Ethiopia

[23] Arba Minch Univ, Dept Midwifery, Arba Minch, Ethiopia

[24] Arba Minch Univ, Dept Anat, Arba Minch, Ethiopia

[25] Arba Minch Univ, Dept Publ Hlth, Arba Minch, Ethiopia

[26] Arba Minch Univ, Dept Med Lab Sci, Arba Minch, Ethiopia

[27] Yasuj Univ Med Sci, Lab Technol Sci Dept, Yasuj, Iran

[28] Yasuj Univ Med Sci, Dept Nursing, Yasuj, Iran

[29] Univ Hlth & Allied Sci, Dept Family & Community Hlth, Ho, Ghana

[30] Univ Hlth & Allied Sci, Inst Hlth Res, Ho, Ghana

[31] Univ Hlth & Allied Sci, Dept Populat & Behav Sci, Ho, Ghana

[32] Univ Tehran Med Sci, Res Ctr Immunodeficiencies, Tehran, Iran

[33] Univ Tehran Med Sci, Liver & Pancreatobiliary Dis Res Ctr, Tehran, Iran

[34] Univ Tehran Med Sci, Noncommunicable Dis Res Ctr, Tehran, Iran

[35] Univ Tehran Med Sci, Tehran Heart Ctr, Tehran, Iran

[36] Univ Tehran Med Sci, Dept Cardiol, Tehran, Iran

[37] Univ Tehran Med Sci, Students Sci Res Ctr, Tehran, Iran

[38] Univ Tehran Med Sci, Childrens Med Ctr, Tehran, Iran

[39] Univ Tehran Med Sci, Dept Pediat Cardiol, Tehran, Iran

[40] Univ Tehran Med Sci, Digest Dis Res Inst, Tehran, Iran

[41] Univ Tehran Med Sci, Sch Med, Tehran, Iran

[42] Univ Tehran Med Sci, Endocrinol & Metab Res Inst, Tehran, Iran

[43] Univ Tehran Med Sci, Fac Med, Tehran, Iran

[44] Univ Tehran Med Sci, Shariati Hosp, Tehran, Iran

[45] Univ Tehran Med Sci, Dept Pediat Allergy & Immunol, Tehran, Iran

[46] Karolinska Univ Hosp, Dept Biosci & Nutr, Huddinge, Sweden

[47] Madda Walabu Univ, Dept Publ Hlth, Addis Ababa, Ethiopia

[48] Jimma Univ, Dept Nutr & Dietet, Addis Ababa, Ethiopia

[49] London Sch Hyg & Trop Med, Dept Dis Control, London, England

[50] London Sch Hyg & Trop Med, Dept Med Stat, London, England

来源：

LANCET HAEMATOLOGY | 2023年 / 10卷 / 09期

基金：

中国国家自然科学基金; 澳大利亚国家健康与医学研究理事会; 加拿大健康研究院;

关键词：

MIDDLE-INCOME COUNTRIES; IRON-DEFICIENCY; WOMEN; IMPACT; MORTALITY; CHILDREN; HEALTH; POPULATIONS; OUTCOMES;

D O I：

10.1016/S2352-3026(23)00160-6

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background Anaemia is a major health problem worldwide. Global estimates of anaemia burden are crucial for developing appropriate interventions to meet current international targets for disease mitigation. We describe the prevalence, years lived with disability, and trends of anaemia and its underlying causes in 204 countries and territories. Methods We estimated population-level distributions of haemoglobin concentration by age and sex for each location from 1990 to 2021. We then calculated anaemia burden by severity and associated years lived with disability (YLDs). With data on prevalence of the causes of anaemia and associated cause-specific shifts in haemoglobin concentrations, we modelled the proportion of anaemia attributed to 37 underlying causes for all locations, years, and demographics in the Global Burden of Disease Study 2021. Findings In 2021, the global prevalence of anaemia across all ages was 24 center dot 3% (95% uncertainty interval [UI] 23 center dot 9-24 center dot 7), corresponding to 1 center dot 92 billion (1 center dot 89-1 center dot 95) prevalent cases, compared with a prevalence of 28 center dot 2% (27 center dot 8-28 center dot 5) and 1 center dot 50 billion (1 center dot 48-1 center dot 52) prevalent cases in 1990. Large variations were observed in anaemia burden by age, sex, and geography, with children younger than 5 years, women, and countries in sub-Saharan Africa and south Asia being particularly affected. Anaemia caused 52 center dot 0 million (35 center dot 1-75 center dot 1) YLDs in 2021, and the YLD rate due to anaemia declined with increasing Socio-demographic Index. The most common causes of anaemia YLDs in 2021 were dietary iron deficiency (cause-specific anaemia YLD rate per 100 000 population: 422 center dot 4 [95% UI 286 center dot 1-612 center dot 9]), haemoglobinopathies and haemolytic anaemias (89 center dot 0 [58 center dot 2-123 center dot 7]), and other neglected tropical diseases (36 center dot 3 [24 center dot 4-52 center dot 8]), collectively accounting for 84 center dot 7% (84 center dot 1-85 center dot 2) of anaemia YLDs. Interpretation Anaemia remains a substantial global health challenge, with persistent disparities according to age, sex, and geography. Estimates of cause-specific anaemia burden can be used to design locally relevant health interventions aimed at improving anaemia management and prevention. Funding Bill & Melinda Gates Foundation. Copyright (c) 2023 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license.

引用

页码：e713 / e734

页数：22

共 65 条

[1] Evaluation of Hemoglobin Cutoff Levels to Define Anemia Among Healthy Individuals [J].