Role of Biomarkers to Assess the Use of Alcohol

被引：2

作者：

Shetty, Akshay ^{[1
,2
,4
]}

De La Torre, Sergio

Ibrahim, Brittney ^{[2
]}

Hong, Andrew ^{[2
]}

Meza, Julio ^{[3
]}

Saab, Sammy ^{[1
,2
]}

机构：

[1] Univ Calif Los Angeles, Dept Med, Los Angeles, CA USA

[2] Univ Calif Los Angeles, Dept Surg, Los Angeles, CA USA

[3] Univ Calif Los Angeles, Dept Family Med, Los Angeles, CA USA

[4] UCLA Med Ctr, Pfleger Liver Inst, 200 Med Plaza,Suite 214, Los Angeles, CA 90095 USA

来源：

JOURNAL OF CLINICAL GASTROENTEROLOGY | 2023年 / 57卷 / 06期

关键词：

alcohol biomarkers; PEth; phosphatidylethanol; ethyl glucuronide; EARLY LIVER-TRANSPLANTATION; CARBOHYDRATE-DEFICIENT TRANSFERRIN; URINARY ETHYL GLUCURONIDE; BLOOD PHOSPHATIDYLETHANOL; MENTAL-ILLNESS; USE DISORDER; CONSUMPTION; DRINKING; MARKER; HAIR;

D O I：

10.1097/MCG.0000000000001852

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Alcohol-associated liver disease has seen a significant rise in the last 2 decades, with an associated rise in the need for accurate alcohol use assessment. Alcohol use has been associated with poor outcomes in both the pre-liver transplant and post-liver transplant patients. Patients with alcohol use disorder often under-report their alcohol consumption because of varying factors, highlighting the need for objective assessment of alcohol use. Aside from the available self-report questionnaires, multiple serologic biomarkers are currently available to assist clinicians to assess recent alcohol consumption among patients with chronic liver disease, liver transplant candidates, and recipients. In this review, we will assess some of these alcohol biomarkers, discuss their strengths and weakness, and review-available data to discuss their role in pre-liver transplant and post-liver transplant population.

引用

页码：537 / 545

页数：9

共 65 条

[1] Improved detection of alcohol consumption using the novel marker phosphatidylethanol in the transplant setting: results of a prospective study [J].