Role of cancer-associated mesenchymal stem cells in the tumor microenvironment: A review

被引：7

作者：

Wang, Kai-Hung ^{[1
]}

Ding, Dah-Ching ^{[2
,3
,4
,5
]}

机构：

[1] Hualien Tzu Chi Hosp, Buddhist Tzu Chi Med Fdn, Dept Med Res, Hualien, Taiwan

[2] Hualien Tzu Chi Hosp, Buddhist Tzu Chi Med Fdn, Dept Obstet & Gynecol, Hualien, Taiwan

[3] Tzu Chi Univ, Hualien, Taiwan

[4] Tzu Chi Univ, Inst Med Sci, Coll Med, Hualien, Taiwan

[5] Hualien Tzu Chi Hosp, Buddhist Tzu Chi Med Fdn, Dept Obstet & Gynecol, Sect 3,Chung-Yang Rd, Hualien 707, Taiwan

来源：

TZU CHI MEDICAL JOURNAL | 2023年 / 35卷 / 01期

关键词：

Cancer; Immunosuppression; Mesenchymal stem cells; Microenvironment; GASTRIC-CANCER; OSTEOSARCOMA CELLS; STROMAL CELLS; EXTRACELLULAR VESICLES; COLON-CANCER; PROMOTE; CARCINOMA; PROLIFERATION; TRANSITION; MIGRATION;

D O I：

10.4103/tcmj.tcmj_138_22

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Mesenchymal stem cells (MSCs) were applied to the therapy for degenerative diseases, immune, and inflammation. In tumor microenvironments (TME), different sources of MSCs showed that tumor-promoting and -inhibiting effects were mediated by different signaling pathways. Cancer-associated MSCs (CaMSCs) could be recruited from bone marrow or local tissues and mainly showed tumor-promoting and immunosuppressive effects. The transformed CaMSCs preserve the characteristics of stem cells, but the properties of regulating TME are different. Hence, we specifically focus on CaMSCs and discuss the detailed mechanisms of regulating the development of cancer cells and immune cells. CaMSCs could be a potential therapeutic target in various types of cancer. However, the detailed mechanisms of CaMSCs in the TME are relatively less known and need further study.

引用

页码：24 / 30

页数：7

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