Lycopodiastrum casuarinoides: An overview of their phytochemicals, biological activities, structure-activity relationship, biosynthetic pathway and 13C NMR data

被引：5

作者：

Liu, Yang ^{[1
]}

Wang, Qiang ^{[1
]}

Xie, Zhen ^{[1
]}

Zheng, Dong-Kun ^{[3
]}

Li, Jing ^{[2
]}

Tan, Gui-Shan ^{[2
]}

机构：

[1] Gannan Med Univ, Key Lab Prevent & Treatment Cardiovasc & Cerebrova, Minist Educ, Ganzhou 341000, Jiangxi, Peoples R China

[2] Cent South Univ, Xiangya Hosp, Natl Clin Res Ctr Geriatr Disorders, Dept Pharm, Changsha 410008, Hunan, Peoples R China

[3] Gannan Med Univ, Coll Pharm, Natl Engn Res Ctr Modernizat Tradit Chinese Med, Hakka Med Resources Branch, Ganzhou 341000, Jiangxi, Peoples R China

来源：

FITOTERAPIA | 2023年 / 165卷

关键词：

Lycopodiastrum casuarinoides; Phytochemical; Biological activities; Structure-activity relationship; Biosynthetic; C-13; NMR; LYCODINE-TYPE ALKALOIDS; HUPERZINE-A; CHOLINESTERASE-INHIBITORS; PARKINSONS-DISEASE; AERIAL PARTS; BUTYRYLCHOLINESTERASE; ANALOGS;

D O I：

10.1016/j.fitote.2022.105425

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Huperzine A, a lycodine-type alkaloid, exhibits potent inhibitory activity against acetylcholinesterase (AChE) and has been utilized to treat neurodegenerative diseases' symptoms. Lycopodiastrum casuarinoides, a member of the family Lycopodiaceae, is renowned for its lycodine-type alkaloids. Some of these alkaloids show various pharmacological benefits, such as anti-cholinesterase, neuroprotective, and cytotoxic effects. To date, 113 chemical compounds, including seventy-four lycodine-type alkaloids, ten terpenoids, eleven aliphatics, and eighteen other compounds, have been isolated from this plant. In this review, we have discussed phytochemicals and biological activities of the reported compounds of L. casuarinoides. Moreover, structure-activity relationship (SAR), plausible biosynthetic pathways, and 13C nuclear magnetic resonance spectroscopy (13C NMR) data of the lycodine-type alkaloids are also summarized.

引用

页数：11

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