Falls Predict Acute Hospitalization in Parkinson's Disease

被引：8

作者：

Santos Garcia, Diego ^{[1
]}

de Deus Fonticoba, Teresa ^{[2
]}

Cores, Carlos ^{[1
]}

Suarez Castro, Ester ^{[2
]}

Hernandez Vara, Jorge ^{[3
,4
]}

Jesus, Silvia ^{[5
,6
]}

Mir, Pablo ^{[5
,6
]}

Cosgaya, Marina ^{[7
]}

Jose Marti, Maria ^{[7
]}

Pastor, Pau ^{[8
]}

Cabo, Iria ^{[9
]}

Seijo, Manuel ^{[9
]}

Legarda, Ines ^{[10
]}

Vives, Barbara ^{[10
]}

Caballol, Nuria ^{[11
]}

Ruiz Martinez, Javier ^{[12
]}

Croitoru, Ioana ^{[12
]}

Cubo, Esther ^{[13
]}

Miranda, Javier ^{[13
]}

Alonso Losada, Maria Gema ^{[14
]}

Labandeira, Carmen ^{[14
]}

Lopez Ariztegui, Nuria ^{[15
]}

Morales-Casado, Mabel ^{[15
]}

Gonzalez Aramburu, Isabel ^{[16
]}

Infante, Jon ^{[16
]}

Escalante, Sonia ^{[17
]}

Bernardo, Noemi ^{[17
]}

Blazquez Estrada, Marta ^{[18
]}

Menendez Gonzalez, Manuel ^{[8
]}

Garcia Caldentey, Juan ^{[19
]}

Borrue, Carmen ^{[20
]}

Vela, Lydia ^{[21
]}

Jose Catalan, Maria ^{[22
]}

Gomez Mayordomo, Victor ^{[22
]}

Kurtis, Monica ^{[23
]}

Prieto, Cristina ^{[24
]}

Ordas, Carlos ^{[24
]}

Nogueira, Victor ^{[25
]}

Lopez Manzanares, Lydia ^{[26
]}

Avila Rivera, Maria Asuncion ^{[27
]}

Puente, Victor ^{[28
]}

Garcia Moreno, Jose Manuel ^{[29
]}

Solano Vila, Berta ^{[30
]}

Alvarez Sauco, Maria ^{[31
]}

Carrillo Padilla, Francisco ^{[32
]}

Martinez Castrillo, Juan Carlos ^{[33
]}

Sanchez Alonso, Pilar ^{[34
]}

Gaston, Itziar ^{[35
]}

Kulisevsky, Jaime ^{[6
,36
]}

Valero, Caridad ^{[37
]}

机构：

[1] Complejo Hosp Univ A Coruna, CHUAC, La Coruna, Spain

[2] Complejo Hosp Univ Ferrol, CHUF, La Coruna, Spain

[3] Vail DHebron Universitary Campus, Neurol Dept, Barcelona, Spain

[4] Vail DHebron Universitary Campus, Neurodegenerat Dis Res, Barcelona, Spain

[5] Hosp Univ Virgen Rocio CSIC Univ Sevilla, Inst Biomed Sevilla, Serv Neurol & Neurofisiol Clin, Unidad Trastornos Movimiento, Seville, Spain

[6] CIBERNED Ctr Invest Biomed Red Enfermedades Neuro, Seville, Spain

[7] Hosp Clin Barcelona, Barcelona, Spain

[8] Univ Hosp Mutua Terrassa, Movement Disorders Unit, Barcelona, Spain

[9] Complejo Hosp Univ Pontevedra Chop, Pontevedra, Spain

[10] Hosp Univ Son Espases, Palma De Mallorca, Spain

[11] Hosp Moises Broggi, Consorci Sanitari Integral, St Joan Despi, Barcelona, Spain

[12] Hosp Univ Donostia, San Sebastian, Spain

[13] Complejo Asistencial Univ Burgos, Burgos, Spain

[14] Complejo Hosp Univ Vigo CHUVI, Hosp Alvaro Cunqueiro, Vigo, Spain

[15] Complejo Hosp Toledo, Toledo, Spain

[16] Hosp Univ Marques de Valdecilla, Santander, Spain

[17] Hosp Tortosa Verge de la Cinta HTVC, Tarragona, Spain

[18] Hosp Univ Cent Asturias, Oviedo, Spain

[19] Ctr Neurol Oms, Palma De Mallorca, Spain

[20] Hosp Infanta Sofia, Madrid, Spain

[21] Fdn Hosp Alcorcon, Madrid, Spain

[22] Hosp Univ Clin San Carlos, Madrid, Spain

[23] Hosp Ruber Int, Madrid, Spain

[24] Hosp Rey Juan Carlos, Madrid, Spain

[25] Hosp Costa, Lugo, Spain

[26] Hosp Univ La Princesa, Madrid, Spain

[27] Hosp Gen LHosp, Consorci Sanitari Integral, Barcelona, Spain

[28] Hosp Mar, Barcelona, Spain

[29] Hosp Univ Virgen Macarena, Seville, Spain

[30] Inst Assistencia Sanitaria IAS Inst Catala Salut, Girona, Spain

[31] Hosp Gen Univ Elche, Elche, Spain

[32] Hosp Univ Canarias, San Cristobal De La Lagu, Santa Cruz De T, Spain

[33] Hosp Univ Ramon y Cajal, Madrid, Spain

[34] Hosp Univ Puerta Hierro, Madrid, Spain

[35] Complejo Hosp Navarra, Pamplona, Spain

[36] Hosp Santa Creu & Sant Pau, Barcelona, Spain

[37] Hosp Arnau Vilanova, Valencia, Spain

[38] Hosp Univ Lucus Augusti HULA, Lugo, Spain

[39] Complejo Hosp Univ Orense CHUO, Orense, Spain

来源：

JOURNAL OF PARKINSONS DISEASE | 2023年 / 13卷 / 01期

关键词：

Falls; hospitalization; non-motor symptoms; Parkinson's disease; predictors; BURDEN; ADMISSIONS; REASONS; CARE;

D O I：

10.3233/JPD-212539

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Background: There is a need for identifying risk factors for hospitalization in Parkinson's disease (PD) and also interventions to reduce acute hospital admission. Objective: To analyze the frequency, causes, and predictors of acute hospitalization (AH) in PD patients from a Spanish cohort. Methods: PD patients recruited from 35 centers of Spain from the COPPADIS-2015 (COhort of Patients with PArkinson's DIsease in Spain, 2015) cohort from January 2016 to November 2017, were included in the study. In order to identify predictors of AH, Kaplan-Meier estimates of factors considered as potential predictors were obtained and Cox regression performed on time to hospital encounter 1-year after the baseline visit. Results: Thirty-five out of 605 (5.8%) PD patients (62.5 +/- 8.9 years old; 59.8% males) presented an AH during the 1-year follow-up after the baseline visit. Traumatic falls represented the most frequent cause of admission, being 23.7% of all acute hospitalizations. To suffer from motor fluctuations (HR [hazard ratio] 2.461; 95% CI, 1.065-5.678; p = 0.035), a very severe non-motor symptoms burden (HR [hazard ratio] 2.828; 95% CI, 1.319-6.063; p = 0.008), falls (HR 3.966; 95% CI 1.757-8.470; p = 0.001), and dysphagia (HR 2.356; 95% CI 1.124-4.941; p = 0.023) was associated with AH after adjustment to age, gender, disease duration, levodopa equivalent daily dose, total number of non-antiparkinsonian drugs, and UPDRS-IIIOFF. Of the previous variables, only falls (HR 2.998; 95% CI 1.080-8.322; p = 0.035) was an independent predictor of AH. Conclusion: Falls is an independent predictor of AH in PD patients.

引用

页码：105 / 124

页数：20

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