On the role of serotonin 5-HT1A receptor in autistic-like behavior: cross talk of 5-HT and BDNF systems

被引：8

作者：

Kondaurova, Elena M. ^{[1
]}

Belokopytova, Irina I. ^{[1
]}

Kulikova, Elisabeth A. ^{[1
]}

Khotskin, Nikita V. ^{[1
]}

Ilchibaeva, Tatiana V. ^{[1
]}

Tsybko, Anton S. ^{[1
]}

Popova, Nina K. ^{[1
]}

Naumenko, Vladimir S. ^{[1
,2
]}

机构：

[1] Russian Acad Sci, Siberian Branch, Fed Res Ctr Inst Cytol & Genet, Akad Lavrentyeva Ave 10, Novosibirsk 630090, Russia

[2] Russian Acad Sci, Inst Cytol & Genet, Siberian Branch, Akad Lavrentyeva Ave 10, Novosibirsk 630090, Russia

来源：

BEHAVIOURAL BRAIN RESEARCH | 2023年 / 438卷

基金：

俄罗斯科学基金会;

关键词：

Serotonin system; 5-HT1A receptor; 5-HT7; receptor; BDNF system; TrkB; AAV-mediated overexpression; Autism spectrum disorder; Autistic-like behavior; BTBR mice; PLUS TF/J MOUSE; NEUROTROPHIC FACTOR; SPECTRUM DISORDER; GENE-EXPRESSION; MAJOR DEPRESSION; BRAIN; MICE; RAT; NEUROPLASTICITY; ANTAGONIST;

D O I：

10.1016/j.bbr.2022.114168

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Autism spectrum disorders (ASDs) are some of the most common neurodevelopmental disorders; however, the mechanisms underlying ASDs are still poorly understood. Serotonin (5-HT) and brain-derived neurotrophic factor (BDNF) are known as key players in brain and behavioral plasticity and interact with each other. 5-HT1A receptor is a principal regulator of the brain 5-HT system, which modulates normal and pathological behavior. Here we investigated effects of adeno-associated-virus-based 5-HT1A receptor overexpression in the hippocam-pus of BTBR mice (which are a model of autism) on various types of behavior and on the expression of 5-HT7 receptor, proBDNF, mature BDNF, and BDNF receptors (TrkB and p75NTR). The 5-HT1A receptor overexpression in BTBR mice reduced stereotyped behavior in the marble-burying test and extended the time spent in the center in the open field test. Meanwhile, this overexpression failed to affect social behavior in the three-chambered test, immobility time in the tail suspension test, locomotor activity in the open field test, and associative learning within the "operant wall" paradigm. The 5-HT1A receptor overexpression in the hippocampus raised hippo-campal 5-HT7 receptor mRNA and protein levels. Additionally, the 5-HT1A receptor overexpression lowered both mRNA and protein levels of TrkB receptor but failed to affect proBDNF, mature BDNF, and p75NTR receptor expression in the hippocampus of BTBR mice. Thus, obtained results suggest the involvement of the 5-HT and BDNF systems' interaction mediated by 5-HT1A and TrkB receptors in the mechanisms underlying autistic-like behavior in BTBR mice.

引用

页数：13

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