Scabies in infants and children - a narrative review

Scabies is a human ectoparasitosis caused by Sarcoptes scabei var. hominis. World-wide around 300 million patients are affected. Infants and children have the highest incidence rates. Poverty and overcrowding are social factors contributing to a higher risk of transmission and treatment failure. The leading symptom of the infestation is itch. Complications are bacterial infections that are responsible for mortality. Diagnosis is clinical. Non-invasive imaging technologies like dermoscopy can be used. Polymerase chain reaction (PCR) is less sensitive and specific than microscopy of skin scrapings. Treatment of choice is topical permethrin 5%. Ivermectin is the only oral drug FDA-approved for scabies. It should be used in cases non-responsive to topical therapy and in case of high number of infested patients in addition to topical therapy. Pseudo-resistance to treatment is not uncommon. New drugs are on the horizon.What is Known:center dot Pruritus is the leading symptom causing sleep disturbances and scratching with the risk of secondary bacterial infections.center dot Treatment failure is related to inappropriate application of topical drugs and asymptomatic family members.What is New:center dot COVID-19 pandemic and migration are contributing to an increased incidence of scabies.center dot New compounds to treat scabies are on the horizon.