Postmortem Brain Imaging in Alzheimer's Disease and Related Dementias: The South Texas Alzheimer's Disease Research Center Repository

被引：7

作者：

Li, Karl ^{[1
]}

Rashid, Tanweer ^{[1
]}

Li, Jinqi ^{[2
]}

Honnorat, Nicolas ^{[1
]}

Nirmala, Anoop Benet ^{[1
]}

Fadaee, Elyas ^{[1
]}

Wang, Di ^{[1
]}

Charisis, Sokratis ^{[1
]}

Liu, Hangfan ^{[1
]}

Franklin, Crystal ^{[2
]}

Maybrier, Mallory ^{[1
]}

Katragadda, Haritha ^{[1
]}

Abazid, Leen ^{[2
]}

Ganapathy, Vinutha ^{[3
]}

Valaparla, Vijaya Lakshmi ^{[4
]}

Bagudu, Pradeepthi ^{[1
]}

Vasquez, Eliana ^{[1
]}

Solano, Leigh ^{[1
]}

Clarke, Geoffrey

Maestre, Gladys ^{[5
,6
]}

Richardson, Tim ^{[1
,7
]}

Walker, Jamie ^{[1
,7
]}

Fox, Peter T.

Bieniek, Kevin ^{[1
,8
]}

Seshadri, Sudha ^{[1
]}

Habes, Mohamad ^{[1
,2
]}

机构：

[1] Univ Texas Hlth Sci Ctr San Antonio, Glenn Biggs Inst Neurodegenerat Disorders, 7703 Floyd Curl Dr, San Antonio, TX 78229 USA

[2] Univ Texas Hlth Sci Ctr San Antonio, Res Imaging Inst, San Antonio, TX 78229 USA

[3] Univ Texas Hlth Sci Ctr San Antonio, Dept Neurol, San Antonio, TX 78229 USA

[4] Univ Texas Med Branch, Dept Neurol, Galveston, TX 77555 USA

[5] Univ Texas Rio Grande Valley, Sch Med, Dept Neurosci, Harlingen, TX USA

[6] Univ Texas Rio Grande Valley, Sch Med, Dept Human Genet, Brownsville, TX USA

[7] Icahn Sch Med Mt Sinai, Dept Pathol, New York, NY USA

[8] Univ Texas Hlth Sci Ctr San Antonio, Dept Pathol, San Antonio, TX 78229 USA

来源：

JOURNAL OF ALZHEIMERS DISEASE | 2023年 / 96卷 / 03期

基金：

美国国家卫生研究院;

关键词：

Alzheimer's disease; dementia; histopathology; magnetic resonance imaging; neuroimaging; postmortem diagnosis; FRONTOTEMPORAL LOBAR DEGENERATION; ENLARGED PERIVASCULAR SPACES; ENABLED DIPOLE INVERSION; WHITE-MATTER; NEUROPATHOLOGIC ASSESSMENT; IRON ACCUMULATION; LEWY BODIES; MRI; DIAGNOSIS; DEPOSITION;

D O I：

10.3233/JAD-230389

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Background: Neuroimaging bears the promise of providing new biomarkers that could refine the diagnosis of dementia. Still, obtaining the pathology data required to validate the relationship between neuroimaging markers and neurological changes is challenging. Existing data repositories are focused on a single pathology, are too small, or do not precisely match neuroimaging and pathology findings. Objective: The new data repository introduced in this work, the South Texas Alzheimer's Disease research center repository, was designed to address these limitations. Our repository covers a broad diversity of dementias, spans a wide age range, and was specifically designed to draw exact correspondences between neuroimaging and pathology data. Methods: Using four different MRI sequences, we are reaching a sample size that allows for validating multimodal neuroimaging biomarkers and studying comorbid conditions. Our imaging protocol was designed to capture markers of cerebrovascular disease and related lesions. Quantification of these lesions is currently underway with MRI-guided histopathological examination. Results: A total of 139 postmortem brains (70 females) with mean age of 77.9 years were collected, with 71 brains fully analyzed. Of these, only 3% showed evidence of AD-only pathology and 76% had high prevalence of multiple pathologies contributing to clinical diagnosis. Conclusions: This repository has a significant (and increasing) sample size consisting of a wide range of neurodegenerative disorders and employs advanced imaging protocols and MRI-guided histopathological analysis to help disentangle the effects of comorbid disorders to refine diagnosis, prognosis and better understand neurodegenerative disorders.

引用

页码：1267 / 1283

页数：17

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