Statins are widely prescribed in clinical practice. Statin-induced myopathy is relatively common, benign, and resolves after statin withdrawal. However, statin-associated autoimmune myopathy is an exceptionally rare and devastating complication that can occur any time after statin initiation. It is characterized by persistent muscle weakness and elevated creatine kinase levels that persist after statin withdrawal. Herein, we present a challenging case of a statin-associated autoimmune myopathy that developed after a decade of atorvastatin use that resulted in debilitating weakness. It is important to recognize cases of myopathies wherein statin discontinuation and aggressive immunosuppressive therapy can reduce morbidity and mortality.
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Univ Sao Paulo, Fac Med, Hosp Clin, Div Rheumatol, BR-01246903 Sao Paulo, BrazilUniv Sao Paulo, Fac Med, Hosp Clin, Div Rheumatol, BR-01246903 Sao Paulo, Brazil
Fernandes, Georgea Hermogenes
Zanoteli, Edmar
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Univ Sao Paulo, Fac Med, Hosp Clin, Dept Neurol, BR-01246903 Sao Paulo, BrazilUniv Sao Paulo, Fac Med, Hosp Clin, Div Rheumatol, BR-01246903 Sao Paulo, Brazil
Zanoteli, Edmar
Shinjo, Samuel Katsuyuki
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Univ Sao Paulo, Fac Med, Hosp Clin, Div Rheumatol, BR-01246903 Sao Paulo, BrazilUniv Sao Paulo, Fac Med, Hosp Clin, Div Rheumatol, BR-01246903 Sao Paulo, Brazil
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Mercer Univ, Coll Pharm & Hlth Sci, Atlanta, GA USAMercer Univ, Coll Pharm & Hlth Sci, Atlanta, GA USA
Baggett, Mary Caitlin
Nykamp, Diane
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Mercer Univ, Dept Pharm Practice, Coll Pharm, Atlanta, GA 30341 USA
Emory St Josephs Hosp Atlanta, Atlanta, GA 30342 USAMercer Univ, Coll Pharm & Hlth Sci, Atlanta, GA USA