Vaccination of White-Tailed Deer with Mycobacterium bovis Bacillus Calmette-Guerin (BCG): Effect of Mycobacterium avium ssp. paratuberculosis Infection

被引：0

作者：

Palmer, Mitchell V. ^{[1
]}

Kanipe, Carly ^{[1
,2
]}

Lehman, Kimberly A. ^{[3
]}

Thacker, Tyler C. ^{[3
]}

Putz, Ellie J. ^{[1
]}

Boggiatto, Paola M. ^{[1
]}

机构：

[1] ARS, Bacterial Dis Livestock Res Unit, Natl Anim Dis Ctr, USDA, 1920 Dayton Ave, Ames, IA 50010 USA

[2] Iowa State Univ, Coll Vet Med, Immunobiol Grad Program, 1800 Christensen Dr, Ames, IA 50010 USA

[3] USDA, Natl Vet Serv Labs, Anim & Plant Hlth Inspect Serv, 1920 Dayton Ave, Ames, IA 50010 USA

来源：

MICROORGANISMS | 2023年 / 11卷 / 10期

关键词：

BCG; Johne's disease; mycobacteria; paratuberculosis; tuberculosis; white-tailed deer; ODOCOILEUS-VIRGINIANUS; CERVUS-ELAPHUS; SUBSP PARATUBERCULOSIS; JOHNES-DISEASE; WILD RUMINANTS; TUBERCULOSIS COMPLEX; FARMED DEER; KEY DEER; CATTLE; EFFICACY;

D O I：

10.3390/microorganisms11102488

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

In many parts of the world, bovine tuberculosis eradication efforts are hampered by wildlife reservoirs of Mycobacterium bovis, which serve as a constant source of M. bovis for nearby cattle. The human tuberculosis vaccine, M. bovis BCG has been investigated for use in several wildlife species, including deer. In the US, white-tailed deer in Michigan have been the source of infection for over 82 cattle herds since M. bovis was discovered in free-ranging deer in 1995. The efficacy of BCG may be influenced by many factors, including prior exposure or infection with non-tuberculous mycobacteria, that is, species other than members of the M. tuberculosis complex. M. avium subspecies paratuberculosis (Map) infection is not uncommon in ruminants such as deer. Using natural exposure to Map and experimental infection with M. bovis, we demonstrate that Map infection increased BCG vaccine efficacy as measured by lesion severity scores.

引用

页数：12

共 81 条

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