Consensus recommendations for clinical assessment tools for the diagnosis of posterior cortical atrophy syndrome from the Atypical AD PIA of ISTAART

被引：2

作者：

Pelak, Victoria S. ^{[1
,2
]}

Tang-Wai, David F. ^{[3
]}

Boeve, Bradley F. ^{[4
]}

Bouwman, Femke H. ^{[5
]}

Graff-Radford, Jonathan ^{[4
]}

Rabinovici, Gil ^{[6
]}

Holden, Samantha K. ^{[7
]}

Townley, Ryan A. ^{[8
]}

Day, Gregory S. ^{[9
]}

Whitwell, Jennifer ^{[10
]}

Ossenkoppele, Rik ^{[5
,11
]}

Boon, Baayla D. C. ^{[12
]}

Putcha, Deepti ^{[13
]}

Onyike, Chiadi U. ^{[14
]}

Snyder, Heather ^{[15
]}

Crutch, Sebastian ^{[16
]}

Yong, Keir X. X. ^{[16
]}

机构：

[1] Univ Colorado, Sch Med, Dept Neurol, Acad Off 1,Mailstop B-185,12631 East 17th Ave, Aurora, CO 80045 USA

[2] Univ Colorado, Sch Med, Dept Ophthalmol, Acad Off 1,Mailstop B-185,12631 East 17th Ave, Victoria, CO 80045 USA

[3] Univ Toronto, Dept Med Neurol, Toronto, ON, Canada

[4] Mayo Clin, Dept Neurol, Rochester, MN USA

[5] Vrije Univ Amsterdam, Dept Neurol, Amsterdam, Netherlands

[6] Univ Calif San Francisco, Dept Neurol, San Francisco, CA USA

[7] Univ Colorado, Sch Med, Dept Neurol, Aurora, CO USA

[8] Univ Kansas, Sch Med, Dept Neurol, Kansas City, KS USA

[9] Mayo Clin, Dept Neurol, Jacksonville, FL USA

[10] Mayo Clin, Dept Radiol, Div Neuroradiol, Rochester, MN USA

[11] Lund Univ, Clin Memory Res Unit, Lund, Sweden

[12] Mayo Clin, Dept Neurosci, Jacksonville, FL USA

[13] Harvard Med Sch, Massachusetts Gen Hosp, Dept Psychiat, Boston, MA USA

[14] Johns Hopkins Med Inst, Dept Psychiat, Baltimore, MD USA

[15] Alzheimers Assoc, Med & Sci Relat, Chicago, IL USA

[16] UCL Queen Sq Inst Neurol, Dementia Res Ctr, London, England

来源：

ALZHEIMER'S & DEMENTIA: DIAGNOSIS, ASSESSMENT & DISEASE MONITORING | 2023年 / 15卷 / 03期

关键词：

Alzheimer's disease; assessment tools; Atypical Alzheimer's Disease Professional Interest Area; clinical outcome assessments; PCA clinical features; posterior cortical atrophy; ALZHEIMERS-DISEASE; BIOMARKERS;

D O I：

10.1002/dad2.12474

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

INTRODUCTIONDelay in diagnosis of posterior cortical atrophy (PCA) syndrome is common, and the lack of familiarity with assessment tools for identifying visual cortical dysfunction is a contributing factor. We propose recommendations for the approach to the evaluation of PCA clinical features during the office visit, the neuropsychological evaluation, and the research setting. A recommended screening battery for eye clinics is also proposed.METHODSRecommendations were developed using results from a web-based survey of members of Alzheimer's Association International Society to Advance Alzheimer's Research and Treatment (ISTAART) Atypical Alzheimer's Disease Professional Interest Area (PIA), literature review, and consensus by the PCA assessment working party of the Atypical Alzheimer's Disease PIA.RESULTSSurvey results revealed robust agreement for assessment tool preferences for PCA features, and many respondents indicated that they reserve assessment tools for use only when PCA is suspected. For some PCA features, curated tools were preferred over validated battery tools, particularly for the office visit. Consensus recommendations superseded survey preferences for two core cognitive features within the 2017 PCA diagnostic criteria.DISCUSSIONThese consensus recommendations provide an evaluation framework for PCA clinical features and can facilitate timely and accurate recognition and diagnosis of PCA. Broader use of these tools should be sought, and development and validation of novel PCA clinical outcome assessments are needed to improve our understanding of atypical AD and other dementias and support the inclusion of those with PCA in treatment trials.

引用

页数：12