Abnormal interaction of Rlip with mutant APP/Abeta and phosphorylated tau reduces wild-type Rlip levels and disrupt Rlip function in Alzheimer's disease

被引：6
作者：
Baig, Javaria [1 ]
Sawant, Neha [1 ]
Rawat, Priyanka [1 ]
Reddy, Arubala P. [2 ]
Reddy, P. Hemachandra [1 ,2 ,3 ,4 ,5 ,6 ,7 ]
Kshirsagar, Sudhir [1 ,7 ]
机构：
[1] Texas Tech Univ, Hlth Sci Ctr, Dept Internal Med, Lubbock, TX 79430 USA
[2] Texas Tech Univ, Coll Human Sci, Dept Nutr Sci, 1301 Akron Ave, Lubbock, TX 79409 USA
[3] Texas Tech Univ, Hlth Sci Ctr, Dept Sch Med, Neurol, Lubbock, TX 79430 USA
[4] Texas Tech Univ, Hlth Sci Ctr, Grad Sch Biomed Sci, Publ Hlth Dept, Lubbock, TX 79430 USA
[5] Texas Tech Univ, Hlth Sci Ctr, Sch Hlth Profess, Dept Speech Language & Hearing Sci, Lubbock, TX 79430 USA
[6] Texas Tech Univ, Hlth Sci Ctr, Dept Pharmacol & Neurosci, Lubbock, TX 79430 USA
[7] Texas Tech Univ, Hlth Sci Ctr, Sch Med, Dept Internal Med, Lubbock, TX 79430 USA
来源：
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE | 2024年 / 1870卷 / 01期
关键词：
Alzheimer's disease; Rlip protein; Mitochondrial dysfunction; Oxidative stress;
D O I：
10.1016/j.bbadis.2023.166858
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Alzheimer's disease (AD) is a neurodegenerative disease that affects a large proportion of the aging population. RalBP1 (Rlip) is a stress-activated protein, that plays an important role in aging and neurodegenerative diseases such as Alzheimer's disease. Mutant APP and mutant Tau interact with the Rlip protein which leads to decreased wild-type Rlip levels and disrupt Rlip function in Alzheimer's disease. Rlip is a promising new target for aging, Alzheimer's disease, and other neurological diseases.
引用
收藏
页数：3
相关论文
共 15 条
  • [1] RALBP1 in Oxidative Stress and Mitochondrial Dysfunction in Alzheimer's Disease
    Awasthi, Sanjay
    Hindle, Ashly
    Sawant, Neha A.
    George, Mathew
    Vijayan, Murali
    Kshirsagar, Sudhir
    Morton, Hallie
    Bunquin, Lloyd E.
    Palade, Philip T.
    Lawrence, J. Josh
    Khan, Hafiz
    Bose, Chhanda
    Reddy, P. Hemachandra
    Singh, Sharda P.
    [J]. CELLS, 2021, 10 (11)
  • [2] Accelerated inflammatory aging in Alzheimer's disease and its relation to amyloid, tau, and cognition
    Cullen, Nicholas C.
    Malarstig, Anders
    Stomrud, Erik
    Hansson, Oskar
    Mattsson-Carlgren, Niklas
    [J]. SCIENTIFIC REPORTS, 2021, 11 (01)
  • [3] Hyperphosphorylation of Microtubule-Associated Protein Tau: A Promising Therapeutic Target for Alzheimer Disease
    Gong, C. -X.
    Iqbal, K.
    [J]. CURRENT MEDICINAL CHEMISTRY, 2008, 15 (23) : 2321 - 2328
  • [4] Deregulated mitochondrial microRNAs in Alzheimer's disease: Focus on synapse and mitochondria
    Gowda, Prashanth
    Reddy, P. Hemachandra
    Kumar, Subodh
    [J]. AGEING RESEARCH REVIEWS, 2022, 73
  • [5] Rlip76: An Unexplored Player in Neurodegeneration and Alzheimer's Disease?
    Hindle, Ashly
    Singh, Sharda P.
    Pradeepkiran, Jangampalli Adi
    Bose, Chhanda
    Vijayan, Murali
    Kshirsagar, Sudhir
    Sawant, Neha A.
    Reddy, P. Hemachandra
    [J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2022, 23 (11)
  • [6] An overview of common non-Alzheimer dementias
    Knopman, DS
    [J]. CLINICS IN GERIATRIC MEDICINE, 2001, 17 (02) : 281 - +
  • [7] Protective effects of mitophagy enhancers against amyloid beta-induced mitochondrial and synaptic toxicities in Alzheimer disease
    Kshirsagar, Sudhir
    Sawant, Neha
    Morton, Hallie
    Reddy, Arubala P.
    Reddy, P. Hemachandra
    [J]. HUMAN MOLECULAR GENETICS, 2022, 31 (03) : 423 - 439
  • [8] Intracellular amyloid-β in Alzheimer's disease
    LaFerla, Frank M.
    Green, Kim N.
    Oddo, Salvatore
    [J]. NATURE REVIEWS NEUROSCIENCE, 2007, 8 (07) : 499 - 509
  • [9] Small G protein Ral and its downstream molecules regulate endocytosis of EGF and insulin receptors
    Nakashima, S
    Morinaka, K
    Koyama, S
    Ikeda, M
    Kishida, M
    Okawa, K
    Iwamatsu, A
    Kishida, S
    Kikuchi, A
    [J]. EMBO JOURNAL, 1999, 18 (13) : 3629 - 3642
  • [10] Defective mitophagy in Alzheimer's disease
    Pradeepkiran, Jangampalli Adi
    Reddy, P. Hemachandra
    [J]. AGEING RESEARCH REVIEWS, 2020, 64
12