Drug-resistant epilepsy: Definition, pathophysiology, and management

被引：24

作者：

Mesraoua, Boulenouar ^{[1
,2
,8
,9
]}

Brigo, Francesco ^{[3
]}

Lattanzi, Simona ^{[4
]}

Abou-Khalil, Bassel ^{[5
]}

Al Hail, Hassan ^{[1
,2
]}

Asadi-Pooya, Ali A. ^{[6
,7
]}

机构：

[1] Hamad Med Corp, Neurosci Dept, Doha, Qatar

[2] Weill Cornell Med Coll, Doha, Qatar

[3] Hosp Merano SABES ASDAA, Dept Neurol, Merano, Italy

[4] Marche Polytech Univ, Dept Expt & Clin Med, Neurol Clin, Ancona, Italy

[5] Vanderbilt Univ, Dept Neurol, Nashville, TN USA

[6] Shiraz Univ Med Sci, Epilepsy Res Ctr, Shiraz, Iran

[7] Thomas Jefferson Univ, Jefferson Comprehens Epilepsy Ctr, Dept Neurol, Philadelphia, PA USA

[8] Weill Cornell Med Coll Qatar, 1 Al Rayan St, Doha, Qatar

[9] Hamad Med Corp, 1 Al Rayan St, Doha, Qatar

来源：

JOURNAL OF THE NEUROLOGICAL SCIENCES | 2023年 / 452卷

关键词：

Epilepsy; Seizure; Treatment; Drug resistance; TEMPORAL-LOBE EPILEPSY; INTERSTITIAL THERMAL THERAPY; BLOOD-BRAIN-BARRIER; ANTIEPILEPTIC DRUGS; ADJUNCTIVE CENOBAMATE; P-GLYCOPROTEIN; DOUBLE-BLIND; SEIZURES; EFFICACY; IMPACT;

D O I：

10.1016/j.jns.2023.120766

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

There are currently >51 million people with epilepsy (PWE) in the world and every year >4.9 million people develop new-onset epilepsy. The cornerstone of treatment in PWE is drug therapy with antiseizure medications (ASMs). However, about one-third of PWE do not achieve seizure control and do not respond well to drug therapy despite the use of appropriate ASMs [drug-resistant epilepsy (DRE)]. The aims of the current narrative review are to discuss the definition of DRE, explain the biological underpinnings and clinical biomarkers of this condition, and finally to suggest practical management strategies to tackle this issue appropriately, in a concise manner.

引用

页数：10

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