Chemical Modification of Polysaccharides: A Review of Synthetic Approaches, Biological Activity and the Structure-Activity Relationship

被引：37
|
作者：
Liu, Tianbo [1 ]
Ren, Qianqian [1 ]
Wang, Shuang [1 ]
Gao, Jianing [1 ]
Shen, Congcong [1 ]
Zhang, Shengyu [1 ]
Wang, Yanhong [1 ,2 ]
Guan, Feng [1 ,2 ]
机构：
[1] Heilongjiang Univ Chinese Med, Sch Pharm, 24 Heping Rd, Harbin 150040, Peoples R China
[2] Heilongjiang Univ Chinese Med, Minist Educ, Key Lab Basic & Applicat Res Beiyao, 24 Heping Rd, Harbin 150040, Peoples R China
来源：
MOLECULES | 2023年 / 28卷 / 16期
基金：
中国国家自然科学基金;
关键词：
polysaccharide; chemical modification; biological activity; SULFATED MODIFICATION; CYCLOCARYA-PALIURUS; SELENYLATION MODIFICATION; ANTIOXIDANT ACTIVITIES; SELECTIVE SULFATION; ANTICOAGULANT; BIOACTIVITIES; PURIFICATION; DERIVATIVES; MECHANISM;
D O I：
10.3390/molecules28166073
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Natural polysaccharides are macromolecular substances with great potential owing to their wide biological activity and low toxicity. However, not all polysaccharides have significant pharmacodynamic activity; hence, appropriate chemical modification methods can be selected according to the unique structural characteristics of polysaccharides to assist in enhancing and promoting the presentation of their biological activities. This review summarizes research progress on modified polysaccharides, including common chemical modification methods, the change in biological activity following modification, and the factors affecting the biological activity of chemically modified polysaccharides. At the same time, the difficulties and challenges associated with the structural modification of natural polysaccharides are also outlined in this review. Thus, research on polysaccharide structure modification is critical for improving the development and utilization of sugar products.
引用
收藏
页数：23
相关论文
共 50 条
  • [41] Insight into the Synthesis, Biological Activity, and Structure-activity Relationship of Benzothiazole and Benzothiazole-hydrazone Derivatives: A Comprehensive Review
    Singh, Himanshu
    Kumar, Rajnish
    Yadav, Ranjeet Kumar
    Mazumder, Avijit
    Salahuddin
    Chauhan, Bharti
    Abdullah, Mohd Mustaqeem
    MINI-REVIEWS IN MEDICINAL CHEMISTRY, 2023, 23 (05) : 537 - 575
  • [42] Polysaccharides from Traditional Chinese Medicines: Extraction, Purification, Modification, and Biological Activity
    Chen, Yun
    Yao, Fangke
    Ming, Ke
    Wang, Deyun
    Hu, Yuanliang
    Liu, Jiaguo
    MOLECULES, 2016, 21 (12)
  • [43] Quinoline-hydrazone Conjugates: Recent Insights into Synthetic Strategies, Structure-activity Relationship, and Biological Activities
    Kumar, Upendra
    Kumar, Rajnish
    Mazumder, Avijit
    Kumar, Greesh
    LETTERS IN DRUG DESIGN & DISCOVERY, 2024, 21 (14) : 2853 - 2874
  • [44] Synthesis and Antiplatelet Activity of Antithrombotic Thiourea Compounds: Biological and Structure-Activity Relationship Studies
    Lourenco, Andre Luiz
    Saito, Max Seidy
    Gomes Dorneles, Luis Eduardo
    Viana, Gil Mendes
    Sathler, Plinio Cunha
    de Sequeira Aguiar, Lucia Cruz
    de Padula, Marcelo
    Souza Domingos, Thaisa Francielle
    Manssour Fraga, Aline Guerra
    Rodrigues, Carlos Rangel
    de Sousa, Valeria Pereira
    Castro, Helena Carla
    Cabral, Lucio Mendes
    MOLECULES, 2015, 20 (04): : 7174 - 7200
  • [45] A review on chemical modification of polysaccharides
    Qu, Chenling
    Wang, Jinshui
    Jin, Huali
    He, Baoshan
    Luo, Li
    ISBE 2011: 2011 INTERNATIONAL CONFERENCE ON BIOMEDICINE AND ENGINEERING, VOL 2, 2011, : 70 - 72
  • [46] Chromone-Fused Cytosine Analogues: Synthesis, Biological Activity, and Structure-Activity Relationship
    Haveliwala, Dhaval D.
    Kamdar, Nimesh R.
    Mistry, Prashant T.
    Patel, Saurabh K.
    NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS, 2014, 33 (02): : 80 - 91
  • [47] Oligostilbenoids investigation of structure-activity relationship with chemical biology information
    Li, Haidi
    Yin, Weiping
    Liu, Pu
    Liu, Huaqing
    2015 SEVENTH INTERNATIONAL CONFERENCE ON MEASURING TECHNOLOGY AND MECHATRONICS AUTOMATION (ICMTMA 2015), 2015, : 716 - 718
  • [48] Structure and biological activity of polysaccharides from Nitraria sibirica pall fruit
    Abuduwaili, Aytursun
    Mutailifu, Paiheerding
    Nuerxiati, Rehebati
    Gao, Yanhua
    Aisa, Haji Akber
    Yili, Abulimiti
    FOOD BIOSCIENCE, 2021, 40
  • [49] Recent Advances in the Structure, Extraction, and Biological Activity of Sargassum fusiforme Polysaccharides
    Zhang, Shun
    Chen, Liang
    Shang, Nan
    Wu, Kefeng
    Liao, Wang
    MARINE DRUGS, 2025, 23 (03)
  • [50] Recent trends in chemical modification and antioxidant activities of plants-based polysaccharides: A review
    Ahmad, Muhammad Muneeb
    CARBOHYDRATE POLYMER TECHNOLOGIES AND APPLICATIONS, 2021, 2
12345