Acellular nerve grafts with bone marrow mesenchymal stem cells/Schwann cells for sciatic nerve regeneration in rats: a meta-analysis

被引：3
|
作者：
Liang, Jie [1 ]
Luo, Liang [1 ]
Xiang, Feifan [1 ]
Lan, Shuang-Li [2 ]
Tan, Xiao-Qi [3 ]
Gu, Hao [1 ]
Yang, Kai-Wen [1 ]
Ye, Junwu [1 ]
Tang, Lian [1 ]
Yang, Yunkang [1 ,4 ]
机构：
[1] Southwest Med Univ, Dept Bone & Joint Surg, Affiliated Hosp, Luzhou, Peoples R China
[2] Southwest Med Univ, Dept Hepatobiliary Surg, Affiliated Hosp, Luzhou, Peoples R China
[3] Southwest Med Univ, Dept Dermatol, Affiliated Hosp, Luzhou, Peoples R China
[4] 25 TaiPing St, Luzhou 646000, Sichuan, Peoples R China
来源：
JOURNAL OF NEUROSURGICAL SCIENCES | 2023年 / 67卷 / 02期
关键词：
Peripheral nerves; Mesenchymal stem cells; Schwann cells; Meta-analysis; ALLOGRAFTS; DEFECTS; REPAIR; CONDUITS;
D O I：
10.23736/S0390-5616.22.05600-4
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
INTRODUCTION: The aim of this meta-analysis was to evaluate the effects of acellular nerve grafts (ANGs) with bone marrow mesenchymal stem cells (BMSCs) or Schwann cells (SCs) on the treatment of sciatic nerve defect in rats.EVIDENCE ACQUISITION: Electronic databases were accessed to identify eligible targets. ANGs data were extracted for meta-analysis using Review Manager 5.3.EVIDENCE SYNTHESIS: The rats subjected to ANGs+BMSCs or ANGs+SCs are characterized by different sciatic nerve function index, nerve conduction, latency, amplitude, myelin sheath thickness, myelinated nerve fibers and gastrocnemius wet weight. accompanied with evidently superior recovery of limb function. These differences are of statistical significance (P<0.05) when compared to that of control group with ANGs only.CONCLUSIONS: ANGs with BMSCs or SCs can promote nerve regeneration and functional recovery in peripheral nerve defects.
引用
收藏
页码：241 / 247
页数：7
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