Protective role of Dodonaea viscosa extract against streptozotocin-induced hepatotoxicity and nephrotoxicity in rats

被引:3
作者
Alanazi, Ahmed Z. [1 ,4 ]
Al-Rejaie, Salim S. [1 ]
Ahmed, Mohammed M. [1 ]
Alhazzani, Khalid [1 ]
Alhosaini, Khaled [1 ]
Sobeai, Homood M. As [1 ]
Alsanea, Sary [1 ]
Alam, Perwez [2 ]
Almarfadi, Omer M. [2 ]
Alqahtani, Ali S. [2 ]
Alhamed, Abdullah S. [1 ]
Alqinyah, Mohammed [1 ]
Alhamami, Hussain N. [1 ]
Almutery, Mohammed F. [3 ]
Mohany, Mohamed [1 ]
机构
[1] King Saud Univ, Coll Pharm, Dept Pharmacol & Toxicol, POB 55760, Riyadh 1145, Saudi Arabia
[2] King Saud Univ, Coll Pharm, Dept Pharmacognosy, POB 55760, Riyadh 1145, Saudi Arabia
[3] King Saud Univ, King Saud Univ Med City, Dept Pathol & Lab Med, Coll Med, Riyadh, Saudi Arabia
[4] King Saud Univ, Coll Pharm, Coll Dent, Dept Pharmacol & Toxicol, Bldg 23,1st Floor,Off 1A 31,POB 2457, Riyadh 11451, Saudi Arabia
关键词
Dodonaea viscosa; Diabetes; Streptozotocin; Oxidative stress; Inflammation; ANTIINFLAMMATORY ACTIVITY; DIABETIC-NEPHROPATHY; OXIDATIVE STRESS; HAUTRIWAIC ACID; INFLAMMATION; ANTIOXIDANT; BARK;
D O I
10.1016/j.jsps.2023.06.002
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Previous investigations have shown that D. viscosa herbal extract is often used to treat a variety of diseases. Therefore, the purpose of this study was to investigate any additional potential impacts on rat liver and kidney damage induced by diabetes. Streptozotocin (STZ) (60 mg/kg/day) was given as a single dosage to cause type 1 diabetes. After then, diabetic rats received oral doses of D. viscosa for four weeks at 150 and 300 mg/kg/day. Blood, liver, and kidney tissues were collected at the end of the treatment and examined. Analysis was made of the serum lipid profile, liver, and kidney functions, as well as blood biochemistry. Moreover, the levels of tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), interleukin-1 beta (IL-1 beta), prostaglandin E-2 (PGE-2), and nitric oxide (NO) were estimated in serum. In liver and kidney samples, thiobarbituric acid reactive substances (TBARs) and reduced glutathione (GSH), as well as the pro-inflammatory cytokines and enzymatic activities of glutathione peroxidase (GPx), glutathione reeducates (GR), glutathione-S-transferase (GST), catalase (CAT), and superoxide dismutase (SOD) were analyzed. Histological changes in liver and kidney cross-sections were also observed. Our findings demonstrated that D. viscosa dramatically decreased pro-inflammatory indicators in blood, kidney, and liver tissues as well as blood glucose, and restored insulin levels, and lipid profiles. Additionally, it significantly raises the antioxidant enzyme activity SOD, CAT, GPx, and GST, while significantly lowering TBARs levels. The above-mentioned biochemical changes that took place in tissues were further supported by histological alterations. These findings imply that D. viscosa protects against STZ-induced hyperglycemia, aberrant lipid synthesis, and oxidative stress and that these benefits may be mediated by interacting with various targets to increase the levels of antioxidant enzymes in the liver and kidneys. Its mode of action and safety for use as medicine against various metabolic problems caused by diabetes require more research. (c) 2023 The Authors. Published by Elsevier B.V. on behalf of King Saud University. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
引用
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页数:12
相关论文
共 53 条
[1]   Silica nanoparticles aggravated the metabolic associated fatty liver disease through disturbed amino acid and lipid metabolisms-mediated oxidative stress [J].
Abulikemu, Alimire ;
Zhao, Xinying ;
Xu, Hailin ;
Li, Yan ;
Ma, Ru ;
Yao, Qing ;
Wang, Ji ;
Sun, Zhiwei ;
Li, Yanbo ;
Guo, Caixia .
REDOX BIOLOGY, 2023, 59
[2]  
Ahmad M, 2012, PAK VET J, V32, P50
[3]  
Akwu Nneka., 2020, ANTIBACTERIAL ANTIOX, V21
[4]  
Al-Attar Atef M, 2010, Saudi J Biol Sci, V17, P295, DOI 10.1016/j.sjbs.2010.05.007
[5]  
Al-Snafi A.E., 2017, IOSR J. Pharm., V7, P10
[6]   Hautriwaic acid as one of the hepatoprotective constituent of Dodonaea viscosa [J].
Ali, Hamid ;
Kabir, Nurul ;
Muhammad, Akhtar ;
Shah, Mohammad Raza ;
Musharraf, Syed Ghulam ;
Iqbal, Naveed ;
Nadeem, Said .
PHYTOMEDICINE, 2014, 21 (02) :131-140
[7]   In vivo Assessment of Combined Effects of Glibenclamide and Losartan in Diabetic Rats [J].
Alotaibi, Moureq R. ;
Fatani, Amal J. ;
Almnaizel, Ahmed T. ;
Ahmed, Mohammed M. ;
Abuohashish, Hatem M. ;
Al-Rejaie, Salim S. .
MEDICAL PRINCIPLES AND PRACTICE, 2019, 28 (02) :178-185
[8]   Angiotensin II receptor Neprilysin inhibitor (LCZ696) compared to Valsartan attenuates Hepatotoxicity in STZ-induced hyperglycemic rats [J].
Alqahtani, Faleh ;
Mohany, Mohamed ;
Alasmari, Abdullah F. ;
Alanazi, Ahmed Z. ;
Belali, Osamah M. ;
Ahmed, Mohammed M. ;
Al-Rejaie, Salim S. .
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES, 2020, 17 (18) :3098-3106
[9]   Gastroprotective effect of Dodonaea viscosa on various experimental ulcer models [J].
Arun, M. ;
Asha, V. V. .
JOURNAL OF ETHNOPHARMACOLOGY, 2008, 118 (03) :460-465
[10]   The pathogenesis of myocardial fibrosis in the setting of diabetic cardiomyopathy [J].
Asbun, J ;
Villarreal, FJ .
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2006, 47 (04) :693-700