An Update on Tamoxifen and the Chemo-Preventive Potential of Vitamin E in Breast Cancer Management

被引：5

作者：

Khallouki, Farid ^{[1
,2
]}

Hajji, Lhoussain ^{[2
]}

Saber, Somayya ^{[1
,2
]}

Bouddine, Toufik ^{[2
]}

Edderkaoui, Mouad ^{[3
,4
,5
]}

Bourhia, Mohammed ^{[6
]}

Mir, Nora ^{[2
]}

Lim, Adrian ^{[3
,4
,5
]}

El Midaoui, Adil ^{[1
]}

Giesy, John P. ^{[7
,8
,9
,10
]}

Aboul-Soud, Mourad A. M. ^{[11
]}

Silvente-Poirot, Sandrine ^{[12
,13
]}

Poirot, Marc ^{[12
,13
]}

机构：

[1] Moulay Ismail Univ Meknes, FSTE, Biol Dept, BP 609, Errachidia 52000, Morocco

[2] Moulay Ismail Univ Meknes, Fac Sci, Biol Dept, BP 11201 Zitoune, Meknes 50050, Morocco

[3] Cedars Sinai Med Ctr, Dept Med, Los Angeles, CA 90048 USA

[4] Cedars Sinai Med Ctr, Dept Biomed Sci, Los Angeles, CA USA

[5] Univ Calif Los Angeles, Los Angeles, CA 90048 USA

[6] Higher Inst Nursing Profess & Tech Hlth, Laayoune 70000, Morocco

[7] Univ Saskatchewan, Toxicol Ctr, Saskatoon, SK S7N 5B3, Canada

[8] Univ Saskatchewan, Dept Vet Biomed Sci, Saskatoon, SK S7N 5B4, Canada

[9] Michigan State Univ, Dept Integrat Biol, E Lansing, MI 48824 USA

[10] Baylor Univ, Dept Environm Sci, Waco, TX 76706 USA

[11] King Saud Univ, Coll Appl Med Sci, Dept Clin Lab Sci, Med & Mol Genet Res, POB 10219, Riyadh 11433, Saudi Arabia

[12] Univ Toulouse III, Canc Res Ctr Toulouse, CNRS, UMR 5071,UMR 1037,INSERM,Equipe Labellisee Ligue N, F-31037 Toulouse, France

[13] French Network Nutr & Canc Res NACRe Network, F-78350 Jouy En Josas, France

来源：

JOURNAL OF PERSONALIZED MEDICINE | 2023年 / 13卷 / 05期

关键词：

tamoxifen; estrogen receptor; AEBS; ChEH; cholesterol metabolism; cholesterol biosynthesis; oxytserols; breast cancer; cytotoxicity; autophagy; resistance; ALPHA-TOCOPHERYL SUCCINATE; ADJUVANT ENDOCRINE THERAPY; RECEPTOR MODULATORS SERMS; DIETARY-SUPPLEMENT USE; ESTROGEN-RECEPTOR; INDUCED APOPTOSIS; GROWTH-FACTOR; POSTMENOPAUSAL WOMEN; GAMMA-TOCOTRIENOL; CROSS-TALK;

D O I：

10.3390/jpm13050754

中图分类号：

R19 [保健组织与事业（卫生事业管理）];

学科分类号：

摘要：

Breast cancer (BC) is the most common female cancer in terms of incidence and mortality worldwide. Tamoxifen (Nolvadex) is a widely prescribed, oral anti-estrogen drug for the hormonal treatment of estrogen-receptor-positive BC, which represents 70% of all BC subtypes. This review assesses the current knowledge on the molecular pharmacology of tamoxifen in terms of its anticancer and chemo-preventive actions. Due to the importance of vitamin E compounds, which are widely taken as a supplementary dietary component, the review focuses only on the potential importance of vitamin E in BC chemo-prevention. The chemo-preventive and onco-protective effects of tamoxifen combined with the potential effects of vitamin E can alter the anticancer actions of tamoxifen. Therefore, methods involving an individually designed, nutritional intervention for patients with BC warrant further consideration. These data are of great importance for tamoxifen chemo-prevention strategies in future epidemiological studies.

引用

页数：26

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