Development of selenium nanoparticles stabilized by novel polysaccharides from Stauntonia brachyanthera pulp for anti-hepatoma cell proliferation

被引：0

作者：

Yu, Ningxiang ^{[1
]}

Chen, Hui ^{[1
]}

Zongo, Abel Wend-Soo ^{[1
]}

Lu, Yuanchao ^{[1
]}

Nie, Xiaohua ^{[1
]}

Meng, Xianghe ^{[1
]}

机构：

[1] Zhejiang Univ Technol, Coll Food Sci & Technol, Hangzhou 310014, Zhejiang, Peoples R China

来源：

FOOD BIOSCIENCE | 2023年 / 53卷

基金：

中国国家自然科学基金;

关键词：

Stauntonia brachyanthera pulp polysaccharides; Selenium nanoparticles; Structural characterization; Stability; Anti-hepatoma activity; ANTIOXIDANT ACTIVITY; CONSTRUCTION; FRUIT;

D O I：

10.1016/j.fbio.2023.102759

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

In this study, the novel polysaccharides extracted from Stauntonia Brachyanthera pulp were used as stabilizers for the preparation of selenium nanoparticles (SBPPs-SeNPs). The preparation process, structural characterization, stability, and anti-hepatoma cell activity of SBPPs-SeNPs were studied in detail. The results showed that the SBPPs-SeNPs were symmetrical spheres with an average diameter of about 30-40 nm under optimal process parameters. SBPPs interacted with SeNPs via hydroxyl groups on the surface of SBPPs to form C-O-Se bonds. SBPPs-SeNPs exhibited good stability during the 21-day storage period at 4 degrees C, likely due to the interaction between SeNPs and the hydroxyl groups. Moreover, in vitro anti-tumor experiments demonstrated that SBPPs-SeNPs significantly inhibited the proliferation of HepG2 cells in a dose-dependent manner, and induced morphological changes, and cell cycle arrest in S phase. SBPPs-SeNPs also triggered apoptosis in HepG2 cells through the mitochondrial pathway. Our findings suggested that SBPPs-SeNPs have the potential to become novel anti-hepatoma agents.

引用

页数：9