Proteolysis targeting chimeras in non-small cell lung cancer

被引：6

作者：

Hagopian, Garo ^{[1
]}

Grant, Christopher ^{[1
]}

Nagasaka, Misako ^{[2
,3
]}

机构：

[1] Univ Calif Irvine, Med Ctr, Dept Med, Orange, CA USA

[2] Univ Calif Irvine, Med Ctr, Dept Med, Div Hematol & Oncol, Orange, CA 92868 USA

[3] St Marianna Univ, Sch Med, Kawasaki, Japan

来源：

CANCER TREATMENT REVIEWS | 2023年 / 117卷

关键词：

PROTACs; Targeted therapy; EGFR; KRAS; ALK; PROTEIN-DEGRADATION; EGFR; MUTATION; RESISTANCE; KRAS; OSIMERTINIB; HYPOXIA; KINASE; POTENT; PROTAC;

D O I：

10.1016/j.ctrv.2023.102561

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Non-small cell lung cancer (NSCLC) has very poor prognosis in advanced stages. Discovery and application of therapies targeting specific oncogenic driver mutations has greatly improved overall survival. However, targeted therapies are limited in their efficacy due to resistance mutations that may arise with long term use. Proteolysis targeting Chimeras (PROTACs) are a promising approach to combating resistance mutations. PROTACs com-mandeer innate ubiquitination machinery to degrade oncogenic proteins. Here we review the PROTACs that have been developed for targeting common EGFR, KRAS, and ALK mutations.

引用

页数：8

共 88 条

[1]

Aboubakar Nana F, 2019, CANCERS, V11

[2] Genomic analyses identify molecular subtypes of pancreatic cancer [J].

Bailey, Peter ;

Chang, David K. ;

Nones, Katia ;

Johns, Amber L. ;

Patch, Ann-Marie ;

Gingras, Marie-Claude ;

Miller, David K. ;

Christ, Angelika N. ;

Bruxner, Tim J. C. ;

Quinn, Michael C. ;

Nourse, Craig ;

Murtaugh, L. Charles ;

Harliwong, Ivon ;

Idrisoglu, Senel ;

Manning, Suzanne ;

Nourbakhsh, Ehsan ;

Wani, Shivangi ;

Fink, Lynn ;

Holmes, Oliver ;

Chin, Vencssa ;

Anderson, Matthew J. ;

Kazakoff, Stephen ;

Leonard, Conrad ;

Newell, Felicity ;

Waddell, Nick ;

Wood, Scott ;

Xu, Qinying ;

Wilson, Peter J. ;

Cloonan, Nicole ;

Kassahn, Karin S. ;

Taylor, Darrin ;

Quek, Kelly ;

Robertson, Alan ;

Pantano, Lorena ;

Mincarelli, Laura ;

Sanchez, Luis N. ;

Evers, Lisa ;

Wu, Jianmin ;

Pinese, Mark ;

Cowley, Mark J. ;

Jones, Marc D. ;

Colvin, Emily K. ;

Nagrial, Adnan M. ;

Humphrey, Emily S. ;

Chantrill, Lorraine A. ;

Mawson, Amanda ;

Humphris, Jeremy ;

Chou, Angela ;

Pajic, Marina ;

Scarlett, Christopher J. .

NATURE, 2016, 531 (7592) :47-+

[3] Long-Term Survival of Patients with Metastatic Non-Small-Cell Lung Cancer over Five Decades [J].

Bar, Jair ;

Urban, Damien ;

Amit, Uri ;

Appel, Sarit ;

Onn, Amir ;

Margalit, Ofer ;

Beller, Tamar ;

Kuznetsov, Teodor ;

Lawrence, Yaacov .

JOURNAL OF ONCOLOGY, 2021, 2021

[4] Novel drugs targeting EGFR and HER2 exon 20 mutations in metastatic NSCLC [J].

Baraibar, Iosune ;

Mezquita, Laura ;

Gil-Bazo, Ignacio ;

Planchard, David .

CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY, 2020, 148

[5] Primary endothelial cell-specific regulation of hypoxia-inducible factor (HIF)-1 and HIF-2 and their target gene expression profiles during hypoxia [J].

Bartoszewski, Rafal ;

Moszynska, Adrianna ;

Serocki, Marcin ;

Cabaj, Aleksandra ;

Polten, Andreas ;

Ochocka, Renata ;

Dell'Italia, Louis ;

Bartoszewska, Sylwia ;

Kroliczewski, Jaroslaw ;

Dabrowski, Michal D. ;

Collawn, James F. .

FASEB JOURNAL, 2019, 33 (07) :7929-7941

[6] The potential utility of re-mining results of somatic mutation testing: KRAS status in lung adenocarcinoma [J].

Biernacka, Anna ;

Tsongalis, Peter D. ;

Peterson, Jason D. ;

de Abreu, Francine B. ;

Black, Candice C. ;

Gutmann, Edward J. ;

Liu, Xiaoying ;

Tafe, Laura J. ;

Amos, Christopher I. ;

Tsongalis, Gregory J. .

CANCER GENETICS, 2016, 209 (05) :195-198

[7] Targeted Degradation of Oncogenic KRASG12C by VHL-Recruiting PROTACs [J].

Bond, Michael J. ;

Chu, Ling ;

Nalawansha, Dhanusha A. ;

Li, Ke ;

Crews, Craig M. .

ACS CENTRAL SCIENCE, 2020, 6 (08) :1367-1375

[8] Targeted Protein Degradation by Small Molecules [J].

Bondeson, Daniel P. ;

Crews, Craig M. .

ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, VOL 57, 2017, 57 :107-123

[9] The Advantages of Targeted Protein Degradation Over Inhibition: An RTK Case Study [J].

Burslem, George M. ;

Smith, Blake E. ;

Lai, Ashton C. ;

Jaime-Figueroa, Saul ;

McQuaid, Daniel C. ;

Bondeson, Daniel P. ;

Toure, Momar ;

Dong, Hanqing ;

Qian, Yimin ;

Wang, Jing ;

Crew, Andrew P. ;

Hines, John ;

Crews, Craig M. .

CELL CHEMICAL BIOLOGY, 2018, 25 (01) :67-+

[10] Distinct patterns of somatic genome alterations in lung adenocarcinomas and squamous cell carcinomas [J].

Campbell, Joshua D. ;

Alexandrov, Anton ;

Kim, Jaegil ;

Wala, Jeremiah ;

Berger, Alice H. ;

Pedamallu, Chandra Sekhar ;

Shukla, Sachet A. ;

Guo, Guangwu ;

Brooks, Angela N. ;

Murray, Bradley A. ;

Imielinski, Marcin ;

Hu, Xin ;

Ling, Shiyun ;

Akbani, Rehan ;

Rosenberg, Mara ;

Cibulskis, Carrie ;

Ramachandran, Aruna ;

Collisson, Eric A. ;

Kwiatkowski, David J. ;

Lawrence, Michael S. ;

Weinstein, John N. ;

Verhaak, Roel G. W. ;

Wu, Catherine J. ;

Hammerman, Peter S. ;

Cherniack, Andrew D. ;

Getz, Gad ;

Artyomov, Maxim N. ;

Schreiber, Robert ;

Govindan, Ramaswamy ;

Meyerson, Matthew .

NATURE GENETICS, 2016, 48 (06) :607-+

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