The Role of Platelets in Infective Endocarditis

被引：9

作者：

Brai, Mustapha Abdeljalil ^{[1
,2
]}

Hannachi, Nadji ^{[3
]}

El Gueddari, Nabila ^{[1
,4
]}

Baudoin, Jean-Pierre ^{[1
,2
]}

Dahmani, Abderrhamane ^{[1
,2
]}

Lepidi, Hubert ^{[1
,5
]}

Habib, Gilbert ^{[1
,6
]}

Camoin-Jau, Laurence ^{[1
,7
]}

机构：

[1] Aix Marseille Univ, IRD, APHM, MEPHI,IHU Mediterranee Infect, 19-21 Blvd Jean Moulin, F-13005 Marseille, France

[2] IHU Mediterranee Infect, Blvd Jean Moulin, F-13385 Marseille, France

[3] Univ Ferhat Abbas Setif I, Fac Medecine, Lab Biopharm & Pharmacotechnie, Setif 19000, Algeria

[4] Hop La Timone, APHM, Serv Chirurg Cardiaque, Blvd Jean Moulin, F-13385 Marseille, France

[5] Hop La Timone, APHM, Serv Anatomo Pathol, Blvd Jean Moulin, F-13385 Marseille, France

[6] Hop La Timone, APHM, Serv Cardiol, Blvd Jean Moulin, F-13385 Marseille, France

[7] Hop La Timone, APHM, Lab Hematol, Blvd Jean Moulin, F-13385 Marseille, France

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2023年 / 24卷 / 08期

关键词：

infective endocarditis; platelets; Staphylococcus aureus; Viridans streptococci; Enterococcus faecalis; STAPHYLOCOCCUS-AUREUS ENDOCARDITIS; NEUTROPHIL EXTRACELLULAR TRAPS; CLUMPING FACTOR B; ENTEROCOCCUS-FAECALIS; ANTIPLATELET THERAPY; IN-VITRO; STREPTOCOCCUS-SANGUIS; MICROBICIDAL PROTEIN; SURFACE PROTEIN; EMBOLIC EVENTS;

D O I：

10.3390/ijms24087540

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Over the last decade, the incidence of infective endocarditis (IE) has increased, with a change in the frequency of causative bacteria. Early evidence has substantially demonstrated the crucial role of bacterial interaction with human platelets, with no clear mechanistic characterization in the pathogenesis of IE. The pathogenesis of endocarditis is so complex and atypical that it is still unclear how and why certain bacterial species will induce the formation of vegetation. In this review, we will analyze the key role of platelets in the physiopathology of endocarditis and in the formation of vegetation, depending on the bacterial species. We provide a comprehensive outline of the involvement of platelets in the host immune response, investigate the latest developments in platelet therapy, and discuss prospective research avenues for solving the mechanistic enigma of bacteria-platelet interaction for preventive and curative medicine.

引用

页数：16

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