Current advances in antiviral RNA interference in mammals

被引：12
|
作者：
Wang, Jiaxin [1 ,2 ]
Li, Yang [1 ,3 ]
机构：
[1] Chinese Acad Sci, Inst Zool, CAS Key Lab Anim Ecol & Conservat Biol, Beijing, Peoples R China
[2] Fudan Univ, Sch Life Sci, State Key Lab Genet Engn, Shanghai, Peoples R China
[3] Chinese Acad Sci, Inst Zool, CAS Key Lab Anim Ecol & Conservat Biol, Beijing, Peoples R China
来源：
FEBS JOURNAL | 2024年 / 291卷 / 02期
基金：
中国国家自然科学基金;
关键词：
antiviral immunity; antiviral RNAi response; extracellular vesicles; non-cell-autonomous immune response; virus-derived small interfering RNAs; VSR; DOUBLE-STRANDED-RNA; DEFENSE-MECHANISM; IMMUNITY; VIRUSES; DICER; INHIBITION; TRANSCRIPTION; REPLICATION; SUPPRESSION; INFECTION;
D O I：
10.1111/febs.16728
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Mammals have potent innate immune systems that work together to fight against a variety of distinct viruses. In addition to interferon (IFN) response, which has been intensively studied, antiviral RNA interference (RNAi) is gradually being studied. However, previous studies indicated low Dicer activity on double-stranded RNA (dsRNA) substrates in vitro and that IFN response masks or inhibits antiviral RNAi in mammals. Therefore, whether or not the RNAi is functional for antiviral response in mammalian somatic cells is still an ongoing area of research. In this review, we will present the current advances in antiviral RNAi in mammals and focus on three fundamental questions critical to the intense debate about whether RNAi can function as an innate antiviral immunity in mammals.
引用
收藏
页码：208 / 216
页数：9
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