N6-methyladenosine in hematological malignancies: a concise review

被引：2
作者：
Wang, Wan-Jie [1 ]
Xu, Ting-Ting [1 ]
Bao, Jing [1 ,2 ]
机构：
[1] Anhui Med Univ, Affiliated Hosp 1, Dept Hematol, Hefei, Anhui, Peoples R China
[2] Anhui Med Univ, Affiliated Hosp 1, Hefei 230022, Anhui, Peoples R China
来源：
CURRENT OPINION IN HEMATOLOGY | 2023年 / 30卷 / 01期
关键词：
immune cells; leukemia; lymphoma; multiple myeloma; N6-methyladenosine; REGULATORY T-CELLS; MESSENGER-RNA; INDOLEAMINE 2,3-DIOXYGENASE; NUCLEAR-RNA; M(6)A METHYLTRANSFERASE; BINDING-PROTEIN; TUMOR HYPOXIA; IMMUNE CELLS; N-6-METHYLADENOSINE; LEUKEMIA;
D O I：
10.1097/MOH.0000000000000741
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Purpose of reviewHematological malignancies are a kind of systemic cancers mostly related to abnormal differentiation of blood stem cells. Because of the poor prognosis, chemotherapy resistance and common recurrence, new mechanisms and treatment therapies are looking forward to be discovered.Recent findingsOver the years, epigenetic abnormalities have been known to act a key part in occurrence and development of hematological tumors. In the internal modifications on long noncoding eukaryotic mRNA, there is a common type called N6-methyladenosine that can change the expression of target genes and participate in the translation, degradation and splicing of mRNA. M6A is related to a wealth of cancers, such as HNRNPA2B1's elevation in multiple myeloma, METTLE3's elevation in acute myeloid leukemia and lung cancer. Immune cells, playing a significant role in hematological cancers, can also be regulated by m6A.In the review, we summarized the recent progress on hematological malignancies associating with m6A and immune cells, which may offer a new road for the treatment of them.
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页码：4 / 13
页数：10
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