Corynoline protects against zearalenone-induced liver injury by activating the SIRT1/Nrf2 signaling pathway

被引：10

作者：

Sun, Liqun ^{[1
]}

He, Dan ^{[1
]}

Liu, Yuhuan ^{[1
]}

Wei, Yunyun ^{[1
]}

Wang, Li ^{[1
]}

机构：

[1] Jilin Univ, Mycol Res Ctr, Coll Basic Med Sci, Dept Pathogenobiol, Changchun 130021, Jilin, Peoples R China

来源：

JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY | 2023年 / 37卷 / 01期

关键词：

corynoline; liver injury; NF-kappa B; SIRT1; zearalenone; NF-KAPPA-B; MICE; INFLAMMATION; NEUTROPHILS;

D O I：

10.1002/jbt.23224

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Corynoline has been reported to have anti-inflammatory and antioxidative effects. In the present study, the potential protective effects of corynoline against zearalenone (ZEA)-induced liver injury were investigated. ZEA was administered daily for 5 days. Then, liver tissues were used for subsequent experiments. Corynoline attenuated liver histopathological changes induced by ZEA. The production of tumor necrosis factor-alpha and interleukin-1 beta in liver tissues, as well as aspartate aminotransferase and alanine aminotransferase in serum, was also inhibited by corynoline. Meanwhile, ZEA-induced MPO activity and MDA content were both attenuated by corynoline. ZEA-induced NF-kappa B p65 and I kappa Ba phosphorylation were inhibited by corynoline. Furthermore, SIRT1, Nrf2, and HO-1 expression were increased by corynoline. In addition, the protective effects of corynoline against liver injury were reversed by the SIRT1 inhibitor EX-527. Taken together, corynoline protected against ZEA-induced liver injury by activating the SIRT1/Nrf2 signaling pathway.

引用

页数：6

共 24 条

[1] Zerumbone Exhibit Protective Effect against Zearalenone Induced Toxicity via Ameliorating Inflammation and Oxidative Stress Induced Apoptosis [J].

AbuZahra, Hamad Mohammed ;

Rajendran, Peramaiyan ;

Ismail, Mohammad Bani .

ANTIOXIDANTS, 2021, 10 (10)

[2] Drug-induced liver injury:: An analysis of 461 incidences submitted to the Spanish Registry over a 10-year period [J].

Andrade, RJ ;

Lucena, MI ;

Fernández, MC ;

Pelaez, G ;

Pachkoria, K ;

García-Ruiz, E ;

García-Munoz, B ;

González-Grande, R ;

Pizarro, A ;

Durán, JA ;

Jiménez, M ;

Rodrigo, L ;

Romero-Gomez, M ;

Navarro, JM ;

Planas, R ;

Costa, J ;

Borras, A ;

Soler, A ;

Salmerón, J ;

Martin-Vivaldi, R .

GASTROENTEROLOGY, 2005, 129 (02) :512-521

[3] Drug-induced liver injury: Mechanisms and test systems [J].

Bissell, DM ;

Gores, GJ ;

Laskin, DL ;

Hoofnagle, JH .

HEPATOLOGY, 2001, 33 (04) :1009-+

[4]

Deng YL, 2017, AM J TRANSL RES, V9, P4271

[5] Lipopolysaccharide Activates Toll-like Receptor 4 (TLR4)-mediated NF-κB Signaling Pathway and Proinflammatory Response in Human Pericytes [J].

Guijarro-Munoz, Irene ;

Compte, Marta ;

Alvarez-Cienfuegos, Ana ;

Alvarez-Vallina, Luis ;

Sanz, Laura .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2014, 289 (04) :2457-2468

[6] Role of neutrophils in acute inflammatory liver injury [J].

Jaeschke, Hartmut ;

Hasegawa, Tadashi .

LIVER INTERNATIONAL, 2006, 26 (08) :912-919

[7] Protective effects of garcinol in mice with lipopolysaccharide/D-galactosamine-induced apoptotic liver injury [J].

Jing, Yuping ;

Ai, Qing ;

Lin, Ling ;

Dai, Jie ;

Jia, Mengying ;

Zhou, Dan ;

Che, Qian ;

Wan, Jingyuan ;

Jiang, Rong ;

Zhang, Li .

INTERNATIONAL IMMUNOPHARMACOLOGY, 2014, 19 (02) :373-380

[8] Antagonistic crosstalk between NF-κB and SIRT1 in the regulation of inflammation and metabolic disorders [J].

Kauppinen, Anu ;

Suuronen, Tiina ;

Ojala, Johanna ;

Kaarniranta, Kai ;

Salminen, Antero .

CELLULAR SIGNALLING, 2013, 25 (10) :1939-1948

[9] Myeloperoxidase: friend and foe [J].

Klebanoff, SJ .

JOURNAL OF LEUKOCYTE BIOLOGY, 2005, 77 (05) :598-625

[10]

Li L, 2018, AM J TRANSL RES, V10, P957

← 1 2 3 →