Electrochemical C3-methylthiolation of imidazopyridines with dimethyl sulfoxide

被引：13

作者：

Feng, Zhaoyue ^{[1
]}

Fan, Yingsibing ^{[1
]}

Qiang, Congcong ^{[1
]}

Liu, Ping ^{[1
]}

Sun, Peipei ^{[1
]}

机构：

[1] Nanjing Normal Univ, Jiangsu Collaborat Innovat Ctr Biomed Funct Mat, Sch Chem & Mat Sci, Jiangsu Prov Key Lab Mat Cycle Proc & Pollut Contr, Nanjing 210023, Peoples R China

来源：

GREEN CHEMISTRY | 2024年 / 26卷 / 06期

基金：

中国国家自然科学基金;

关键词：

DMSO; 7-MERCAPTO-4-METHYLCOUMARIN; METHYLTHIOLATION; DERIVATIVES; OXIDATION; STRATEGY;

D O I：

10.1039/d4gc00314d

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An efficient electrochemical methylthiolation reaction of imidazo[1,2-a]pyridines was achieved. The method used DMSO as both the methylthiolating reagent and solvent and KI as both the hydrogen atom transfer reagent and supporting electrolyte. The reaction was performed under transition metal- and chemical oxidant-free conditions. For various substituted 2-arylimidazo[1,2-a]pyridines, C-3 methylthiolation products were obtained regioselectively with good yields. An electrochemical C-3 methylthiolation reaction of imidazo[1,2-a]pyridines was achieved. The method used DMSO as both the methylthiolating reagent and solvent and KI as both the hydrogen atom transfer reagent and supporting electrolyte.

引用

页码：3517 / 3521

页数：5

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