Traditional Chinese medicine Pingchan granule for motor symptoms and functions in Parkinson's disease: A multicenter, randomized, double-blind, placebo-controlled study

被引:10
作者
Gu, Si-Chun [1 ]
Shi, Rong [2 ]
Gaoag, Chen [3 ]
Yuan, Xiao-Lei [1 ]
Wu, You [1 ]
Zhang, Yu [3 ]
Wang, Chang De [4 ]
Fan, Rui-Dong [5 ]
Chen, Xiqun [6 ]
Yuan, Can-Xing [1 ]
Ye, Qing [1 ]
机构
[1] Shanghai Univ Tradit Chinese Med, Longhua Hosp, Dept Neurol, 725 South Wanping Rd, Shanghai 200032, Peoples R China
[2] Shanghai Univ Tradit Chinese Med, Shuguang Hosp, Dept Emergency, 528 Zhangheng Rd, Shanghai 201203, Peoples R China
[3] Shanghai Jiao Tong Univ, Xinhua Hosp, Dept Neurol, Sch Med, 1665 Kongjiang Rd, Shanghai 200092, Peoples R China
[4] Shanghai Univ Tradit Chinese Med, Shanghai TCM Integrated Hosp, Dept Neurol, 230 Baoding Rd, Shanghai 200082, Peoples R China
[5] Shigatse Peoples Hosp, Dept Integrated Tradit Chinese & Western Med, Jilin South Rd, Shigatse, Xizang, Peoples R China
[6] Harvard Med Sch, Massachusetts Gen Hosp, Dept Neurol, 114 16th St, Charlestown, MA 02129 USA
基金
中国国家自然科学基金;
关键词
Pingchan granule; Parkinson's disease; Traditional chinese medicine; Motor; gait; quality of life; HUMAN WALKING; CURVED PATH; DIAGNOSIS; FEATURES;
D O I
10.1016/j.phymed.2022.154497
中图分类号
Q94 [植物学];
学科分类号
071001 ;
摘要
Background: Pingchan granule (PCG) is a traditional Chinese medicine for Parkinson's disease (PD). Hypothesis/Purpose: This was the first study aiming to evaluate the efficacy and safety of PCG for motor symp-toms, gait impairments and quality of life in PD. Study Design and Methods: In this multicenter, randomized, double-blind, placebo-controlled trial, 292 partici-pants were included and followed for 9 months, randomly assigned at a 1:1 ratio to receive PCG or placebo. The primary outcome was the severity of motor symptoms assessed by Movement Disorder Society Unified Parkin-son's Rating Scale III (MDS-UPDRS-III) motor score. Secondary outcomes included timed up and go test (TUG), functional gait assessment (FGA), freezing of gait (FOG), and quality of life assessed by Parkinson's disease questionnaire (PDQ-39). Assessments were done at baseline (T0), 3 months (T1), 6 months (T2) and 9 months (T3). Trial registration: Chinese Clinical Trial Register, ChiCTR-INR-1,701,194. Results: Generalized estimating equation analyses revealed that PCG group had significantly better improvement in MDS-UPDRS-III motor score than placebo group, as well as its domain scores of axial symptoms, bradykinesia, rigidity, and tremor. Improvements of TUG time, FGA, FOG questionnaire (FOGQ), and PDQ39 scores were also observed. Conclusion: PCG had a long-lasting efficacy for motor symptoms and function in PD with good tolerance, sup-porting that PCG might be a viable alternative in the management of PD.
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页数:11
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共 36 条
  • [1] Diagnosis and Treatment of Parkinson Disease A Review
    Armstrong, Melissa J.
    Okun, Michael S.
    [J]. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2020, 323 (06): : 548 - 560
  • [2] Diagnosis and Management of Dementia: Review
    Arvanitakis, Zoe
    Shah, Raj C.
    Bennett, David A.
    [J]. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2019, 322 (16): : 1589 - 1599
  • [3] Balance training in individuals with Parkinson's disease: Therapist-supervised vs. home-based exercise programme
    Atterbury, Elizabeth Maria
    Welman, Karen Estelle
    [J]. GAIT & POSTURE, 2017, 55 : 138 - 144
  • [4] Testing functional performance in people with Parkinson disease
    Brusse, KJ
    Zimdars, S
    Zalewski, KR
    Steffen, TM
    [J]. PHYSICAL THERAPY, 2005, 85 (02): : 134 - 141
  • [5] Chow SC., 2008, Section, V3.1.1, P50
  • [6] Low-frequency STN-DBS provides acute gait improvements in Parkinson's disease: a double-blinded randomised cross-over feasibility trial
    Conway, Zachary J.
    Silburn, Peter A.
    Perera, Thushara
    O'Maley, Karen
    Cole, Michael H.
    [J]. JOURNAL OF NEUROENGINEERING AND REHABILITATION, 2021, 18 (01)
  • [7] Human walking along a curved path. II. Gait features and EMG patterns
    Courtine, G
    Schieppati, M
    [J]. EUROPEAN JOURNAL OF NEUROSCIENCE, 2003, 18 (01) : 191 - 205
  • [8] Human walking along a curved path. I. Body trajectory, segment orientation and the effect of vision
    Courtine, G
    Schieppati, M
    [J]. EUROPEAN JOURNAL OF NEUROSCIENCE, 2003, 18 (01) : 177 - 190
  • [9] The placebo treatments in neurosciences - New insights from clinical and neuroimaging studies
    Diederich, Nico J.
    Goetz, Christopher G.
    [J]. NEUROLOGY, 2008, 71 (09) : 677 - 684
  • [10] Global, regional, and national burden of Parkinson's disease, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016
    Dorsey, E. Ray
    Elbaz, Alexis
    Nichols, Emma
    Abd-Allah, Foad
    Abdelalim, Ahmed
    Adsuar, Jose C.
    Ansha, Mustafa Geleto
    Brayne, Carol
    Choi, Jee-Young J.
    Collado-Mateo, Daniel
    Dahodwala, Nabila
    Huyen Phuc Do
    Edessa, Dumessa
    Endres, Matthias
    Fereshtehnejad, Seyed-Mohammad
    Foreman, Kyle J.
    Gbetoho Gankpe, Fortune
    Gupta, Rahul
    Hankey, Graeme J.
    Hay, Simon I.
    Hegazy, Mohamed I.
    Hibstu, Desalegn T.
    Kasaeian, Amir
    Khader, Yousef
    Khalil, Ibrahim
    Khang, Young-Ho
    Kim, Yun Jin
    Kokubo, Yoshihiro
    Logroscino, Giancarlo
    Massano, Joao
    Ibrahim, Norlinah Mohamed
    Mohammed, A. Mohammed
    Mohammadi, Alireza
    Moradi-Lakeh, Maziar
    Naghavi, Mohsen
    Binh Thanh Nguyen
    Nirayo, Yirga Legesse
    Ogbo, Felix Akpojene
    Owolabi, Mayowa Ojo
    Pereira, David M.
    Postma, Maarten J.
    Qorbani, Mostafa
    Rahman, Muhammad Aziz
    Roba, Kedir T.
    Safari, Hosein
    Safiri, Saeid
    Satpathy, Maheswar
    Sawhney, Monika
    Shafieesabet, Azadeh
    Shiferaw, Mekonnen Sisay
    [J]. LANCET NEUROLOGY, 2018, 17 (11) : 939 - 953