Heartfelt Breakthroughs: Elevating Quality of Life with Cutting-Edge Advances in Heart Failure Treatment

被引：2

作者：

Devadoss, Ramprakash ^{[1
]}

Dhillon, Gagandeep ^{[2
]}

Sharma, Pranjal ^{[3
]}

Verma, Ram Kishun ^{[4
]}

Munjal, Ripudaman ^{[5
]}

Kashyap, Rahul ^{[6
]}

机构：

[1] Carle Methodist Hosp, Peoria, IL 61636 USA

[2] UM Baltimore Washington Med Ctr, Dept Med, Glen Burnie, MD 21061 USA

[3] Northeast Ohio Med Univ, Dept Med, Rootstown, OH 44272 USA

[4] Parkview Hlth Syst, Ft Wayne, IN 46845 USA

[5] Kaiser Permanente Med Ctr, Modesto, CA 95356 USA

[6] WellSpan Hlth, 1001 S George St, York, PA 17403 USA

来源：

JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE | 2024年 / 11卷 / 01期

关键词：

heart failure; ARNI; SGLT2; inhibitors; gene therapies; artificial intelligence; PRESERVED EJECTION FRACTION; NATRIURETIC PEPTIDE; GENE-THERAPY; CARDIAC-RESYNCHRONIZATION; MORTALITY; DIAGNOSIS; METAANALYSIS; PREVENTION; BIOMARKERS; GUIDELINES;

D O I：

10.3390/jcdd11010015

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Heart failure is a cardiovascular condition, leading to fatigue, breathlessness, and fluid retention. It affects around 56 million people globally and is a leading cause of hospitalization and mortality. Its prevalence is rising due to aging populations and lifestyle factors. Managing heart failure demands a multidisciplinary approach, encompassing medications, lifestyle modifications, and often medical devices or surgeries. The treatment burden is substantial, impacting patients' daily lives and straining healthcare systems. Improving early detection, novel therapies, and patient education are crucial for alleviating the burden and enhancing the quality of life. There are notable advancements in the field of heart failure treatment and prevention. We will discuss significant pharmacological and device advances related to heart failure, including angiotensin receptor-neprilysin inhibitor, sodium-glucose co-transporter inhibition, glucagon-like peptide-1 agonist, cardiac resynchronization therapy, cardiac contractility modulation, mechanical circulatory support devices, and transcatheter valve interventions. We will also review novel therapies on the horizon, emerging technologies like CRISPR-based treatments for genetic anomalies, and the involvement of artificial intelligence in heart failure detection and management.

引用

页数：12

共 67 条

[1] A Randomized Controlled Trial to Evaluate the Safety and Efficacy of Cardiac Contractility Modulation [J].

Abraham, William T. ;

Kuck, Karl-Heinz ;

Goldsmith, Rochelle L. ;

Lindenfeld, JoAnn ;

Reddy, Vivek Y. ;

Carson, Peter E. ;

Mann, Douglas L. ;

Saville, Benjamin ;

Parise, Helen ;

Chan, Rodrigo ;

Wiegn, Phi ;

Hastings, Jeffrey L. ;

Kaplan, Andrew J. ;

Edelmann, Frank ;

Luthje, Lars ;

Kahwash, Rami ;

Tomassoni, Gery F. ;

Gutterman, David D. ;

Stagg, Angela ;

Burkhoff, Daniel ;

Hasenfuss, Gerd .

JACC-HEART FAILURE, 2018, 6 (10) :874-883

[2] Wireless pulmonary artery haemodynamic monitoring in chronic heart failure: a randomised controlled trial [J].

Abraham, William T. ;

Adamson, Philip B. ;

Bourge, Robert C. ;

Aaron, Mark F. ;

Costanzo, Maria Rosa ;

Stevenson, Lynne W. ;

Strickland, Warren ;

Neelagaru, Suresh ;

Raval, Nirav ;

Krueger, Steven ;

Weiner, Stanislav ;

Shavelle, David ;

Jeffries, Bradley ;

Yadav, Jay S. .

LANCET, 2011, 377 (9766) :658-666

[3] Machine Learning Methods Improve Prognostication, Identify Clinically Distinct Phenotypes, and Detect Heterogeneity in Response to Therapy in a Large Cohort of Heart Failure Patients [J].

Ahmad, Tariq ;

Lund, Lars H. ;

Rao, Pooja ;

Ghosh, Rohit ;

Warier, Prashant ;

Vaccaro, Benjamin ;

Dahlstrom, Ulf ;

O'Connor, Christopher M. ;

Felker, G. Michael ;

Desai, Nihar R. .

JOURNAL OF THE AMERICAN HEART ASSOCIATION, 2018, 7 (08)

[4] Empagliflozin in Heart Failure with a Preserved Ejection Fraction [J].

Anker, Stefan D. ;

Butler, Javed ;

Filippatos, Gerasimos ;

Ferreira, Joao P. ;

Bocchi, Edimar ;

Boehm, Michael ;

Brunner-La Rocca, Hans-Peter ;

Choi, Dong-Ju ;

Chopra, Vijay ;

Chuquiure-Valenzuela, Eduardo ;

Giannetti, Nadia ;

Gomez-Mesa, Juan Esteban ;

Janssens, Stefan ;

Januzzi, James L. ;

Gonzalez-Juanatey, Jose R. ;

Merkely, Bela ;

Nicholls, Stephen J. ;

Perrone, Sergio V. ;

Pina, Ileana L. ;

Ponikowski, Piotr ;

Senni, Michele ;

Sim, David ;

Spinar, Jindrich ;

Squire, Iain ;

Taddei, Stefano ;

Tsutsui, Hiroyuki ;

Verma, Subodh ;

Vinereanu, Dragos ;

Zhang, Jian ;

Carson, Peter ;

Lam, Carolyn Su Ping ;

Marx, Nikolaus ;

Zeller, Cordula ;

Sattar, Naveed ;

Jamal, Waheed ;

Schnaidt, Sven ;

Schnee, Janet M. ;

Brueckmann, Martina ;

Pocock, Stuart J. ;

Zannad, Faiez ;

Packer, Milton .

NEW ENGLAND JOURNAL OF MEDICINE, 2021, 385 (16) :1451-1461

[5] Vericiguat in Patients with Heart Failure and Reduced Ejection Fraction [J].

Armstrong, Paul W. ;

Pieske, Burkert ;

Anstrom, Kevin J. ;

Ezekowitz, Justin ;

Hernandez, Adrian F. ;

Butler, Javed ;

Lam, Carolyn S. P. ;

Ponikowski, Piotr ;

Voors, Adriaan A. ;

Jia, Gang ;

McNulty, Steven E. ;

Patel, Mahesh J. ;

Roessig, Lothar ;

Koglin, Joerg ;

O'Connor, Christopher M. .

NEW ENGLAND JOURNAL OF MEDICINE, 2020, 382 (20) :1883-1893

[6] Adherence to continuous positive airway pressure reduces the risk of 30-day hospital readmission among older adults with comorbid obstructive and cardiovascular disease [J].

Bailey, M. Doyinsola ;

Wickwire, Emerson M. ;

Md, Virend K. Somers ;

Albrecht, Jennifer S. .

JOURNAL OF CLINICAL SLEEP MEDICINE, 2022, 18 (12) :2739-2744

[7] Gene Therapy for Cardiovascular Disease: Basic Research and Clinical Prospects [J].

Cao, Genmao ;

Xuan, Xuezhen ;

Zhang, Ruijing ;

Hu, Jie ;

Dong, Honglin .

FRONTIERS IN CARDIOVASCULAR MEDICINE, 2021, 8

[8] The effect of cardiac resynchronization on morbidity and mortality in heart failure [J].

Cleland, JGF ;

Daubert, J ;

Erdmann, E ;

Freemantle, N ;

Gras, D ;

Kappenberger, L ;

Tavazzi, L ;

Cleland, JGF ;

Daubert, JC ;

Erdmann, E ;

Gras, D ;

Kappenberger, L ;

Klein, W ;

Tavazzi, L ;

Poole-Wilson, PA ;

Rydén, L ;

Wedel, H ;

Wellens, HJJ ;

Uretsky, B ;

Thygesen, K ;

Böcker, D ;

Marijianowski, MMH ;

Freemantle, N ;

Calvert, MJ ;

Christ, G ;

Fruhwald, F ;

Hofmann, R ;

Krypta, A ;

Leisch, F ;

Pacher, R ;

Rauscha, F ;

Tavernier, R ;

Thomsen, PEB ;

Boesgaard, S ;

Eiskjær, H ;

Esperen, GT ;

Haarbo, J ;

Hagemann, A ;

Korup, E ;

Moller, M ;

Mortensen, P ;

Sogaard, P ;

Vesterlund, T ;

Huikuri, H ;

Niemelä, KI ;

Toivonen, L ;

Bauer, F ;

Cohen-Solal, A ;

Crocq, C ;

Djiane, P .

NEW ENGLAND JOURNAL OF MEDICINE, 2005, 352 (15) :1539-1549

[9] Dynamics and prognostic role of galectin-3 in patients with advanced heart failure, during left ventricular assist device support and following heart transplantation [J].

Coromilas, Ellie ;

Que-Xu, Em-Claire ;

Moore, D'Vesharronne ;

Kato, Tomoko S. ;

Wu, Christina ;

Ji, Ruiping ;

Givens, Raymond ;

Jorde, Ulrich P. ;

Takayama, Hiroo ;

Naka, Yoshifumi ;

George, Isaac ;

Mancini, Donna ;

Schulze, P. Christian .

BMC CARDIOVASCULAR DISORDERS, 2016, 16

[10] Galectin-3 as a novel biomarker for disease diagnosis and a target for therapy [J].

Dong, Rui ;

Zhang, Min ;

Hu, Qunying ;

Zheng, Shan ;

Soh, Andrew ;

Zheng, Yijie ;

Yuan, Hui .

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 2018, 41 (02) :599-614

← 1 2 3 4 5 6 7 →