Case report: MRI-negative myelitis following COVID-19 with SEP abnormalities: a case series and literature review

被引：2
作者：
Kawama, Kentaro [1 ]
Shimazaki, Rui [1 ]
Sunami, Yoko [1 ]
Miyakoshi, Natsuki [1 ]
Tobisawa, Shinsuke [1 ]
Shimizu, Toshio [1 ]
Takahashi, Kazushi [1 ]
机构：
[1] Tokyo Metropolitan Neurol Hosp, Dept Neurol, Tokyo, Japan
来源：
FRONTIERS IN NEUROLOGY | 2023年 / 14卷
关键词：
COVID-19; myelitis; SEPs; MRI; microglia;
D O I：
10.3389/fneur.2023.1275696
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Coronavirus Disease 2019 (COVID-19) is known to have various, neurological manifestations. We herein report three patients with MRI-negative myelitis following COVID-19 with abnormal somatosensory evoked potentials (SEPs). Decreased amplitude of the cortical potential and prolonged latency in the SEPs contributed to diagnosing myelitis in the present patients. The SEP findings improved as the neurological symptoms improved. Despite a delay in initiating immunosuppressive treatment after myelitis onset, all the patients improved clinically. In the light of recent progress in COVID-19 research, several hypotheses can be made to explain the pathophysiology underlying MRI-negative myelitis, including antibody-binding and microglial synapse elimination.
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