共 126 条
NAFLD: An Emerging Causal Factor for Cardiovascular Disease
被引:19
作者:

Li, Mei
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机构:
Wuhan Univ, Sch Basic Med Sci, Wuhan, Peoples R China Wuhan Univ, Sch Basic Med Sci, Wuhan, Peoples R China

Wang, Hongmin
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机构:
Huanggang Cent Hosp, Dept Rehabil Med, Huanggang, Peoples R China Wuhan Univ, Sch Basic Med Sci, Wuhan, Peoples R China

Zhang, Xiao-Jing
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机构:
Wuhan Univ, Sch Basic Med Sci, Wuhan, Peoples R China
Wuhan Univ, Inst Model Anim, Wuhan, Peoples R China
Wuhan Univ, Dept Cardiol, Renmin Hosp, Wuhan, Peoples R China Wuhan Univ, Sch Basic Med Sci, Wuhan, Peoples R China

Cai, Jingjing
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h-index: 0
机构:
Wuhan Univ, Inst Model Anim, Wuhan, Peoples R China
Cent South Univ, Xiangya Hosp 3, Dept Cardiol, Changsha, Peoples R China Wuhan Univ, Sch Basic Med Sci, Wuhan, Peoples R China

Li, Hongliang
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h-index: 0
机构:
Wuhan Univ, Sch Basic Med Sci, Wuhan, Peoples R China
Wuhan Univ, Inst Model Anim, Wuhan, Peoples R China
Wuhan Univ, Dept Cardiol, Renmin Hosp, Wuhan, Peoples R China Wuhan Univ, Sch Basic Med Sci, Wuhan, Peoples R China
机构:
[1] Wuhan Univ, Sch Basic Med Sci, Wuhan, Peoples R China
[2] Huanggang Cent Hosp, Dept Rehabil Med, Huanggang, Peoples R China
[3] Wuhan Univ, Inst Model Anim, Wuhan, Peoples R China
[4] Wuhan Univ, Dept Cardiol, Renmin Hosp, Wuhan, Peoples R China
[5] Cent South Univ, Xiangya Hosp 3, Dept Cardiol, Changsha, Peoples R China
来源:
关键词:
atherosclerosis;
cardiovascular disease;
endothelial dysfunction;
heart failure;
NAFLD;
FATTY LIVER-DISEASE;
RENIN-ANGIOTENSIN SYSTEM;
PLACEBO-CONTROLLED TRIAL;
GLP-1 RECEPTOR AGONISTS;
INSULIN-RESISTANCE;
TISSUE FACTOR;
FACTOR VIIA;
RISK;
PROGRESSION;
MECHANISMS;
D O I:
10.1152/physiol.00013.2023
中图分类号:
Q4 [生理学];
学科分类号:
071003 ;
摘要:
Nonalcoholic fatty liver disease (NAFLD) is the most prevalent chronic liver disease worldwide that poses a significant threat to human health. Cardiovascular disease (CVD) is the leading cause of mortality in NAFLD patients. NAFLD and CVD share risk factors such as obesity, insulin resistance, and type 2 diabetes. However, whether NAFLD is a causal risk factor for CVD remains a matter of debate. This review summarizes the evidence from prospective clinical and Mendelian randomization studies that underscore the potential causal relationship between NAFLD and CVD. The mechanisms of NAFLD contributing to the development of CVD and the necessity of addressing CVD risk while managing NAFLD in clinical practice are also discussed.
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页码:255 / 265
页数:11
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