Research progress of small-molecule drugs in targeting telomerase in human cancer and aging

被引：7

作者：

Shen, Ziyi ^{[1
]}

Wang, Yuanhui ^{[1
]}

Wang, Guanzhen ^{[1
,6
]}

Gu, Wei ^{[1
]}

Zhao, Shengchao ^{[1
,6
]}

Hu, Xiaomeng ^{[6
,7
]}

Liu, Wei ^{[6
]}

Cai, Yi ^{[4
,5
]}

Ma, Zhihong ^{[7
]}

Gautam, Rupesh K. ^{[8
]}

Jia, Jia ^{[1
,2
]}

Wan, Chunpeng ^{[3
]}

Yan, Tingdong ^{[1
,2
]}

机构：

[1] Shanghai Univ, Sch Life Sci, 99 Shangda Rd, Shanghai 200444, Peoples R China

[2] Huzhou Univ, Zhejiang Xinda Hosp, Translat Med Ctr, Sch Med & Nursing, Huzhou 313099, Peoples R China

[3] Jiangxi Agr Univ, Coll Agron, Jiangxi Key Lab Postharvest Technol & Nondestruct, Nanchang 330045, Peoples R China

[4] Guangzhou Med Univ, Affiliated Hosp 5, Sch Pharmaceut Sci, Key Lab Mol Target & Clin Pharmacol, Guangzhou 511436, Peoples R China

[5] Guangzhou Med Univ, Affiliated Hosp 5, Sch Pharmaceut Sci, State & NMPA Key Lab Resp Dis, Guangzhou 511436, Peoples R China

[6] Yili Normal Univ, Univ Coll Key Lab Nat Prod Chem & Applicat Xinjian, Sch Chem & Environm Sci, Yining 835000, Peoples R China

[7] Huzhou Cent Hosp, Huzhou 313000, Peoples R China

[8] Indore Inst Pharm, Dept Pharmacol, Indore 453331, India

来源：

CHEMICO-BIOLOGICAL INTERACTIONS | 2023年 / 382卷

基金：

中国国家自然科学基金;

关键词：

Telomeres; Telomerase; Cancer; Aging; Small-molecule drugs; HTERT GENE-EXPRESSION; LONG-TERM EXPOSURE; INHIBITOR MST-312; G-QUADRUPLEX; SYNERGISTICALLY GROWTH; CELL-DEATH; IN-VITRO; IMETELSTAT; HALLMARKS; PROLIFERATION;

D O I：

10.1016/j.cbi.2023.110631

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Telomeres are unique structures located at the ends of linear chromosomes, responsible for stabilizing chromosomal structures. They are synthesized by telomerase, a reverse transcriptase ribonucleoprotein complex. Telomerase activity is generally absent in human somatic cells, except in stem cells and germ cells. Every time a cell divides, the telomere sequence is shortened, eventually leading to replicative senescence and cell apoptosis when the telomeres reach a critical limit. However, most human cancer cells exhibit increased telomerase activity, allowing them to divide continuously. The importance of telomerase in cancer and aging has made developing drugs targeting telomerase a focus of research. Such drugs can inhibit cancer cell growth and delay aging by enhancing telomerase activity in telomere-related syndromes or diseases. This review provides an overview of telomeres, telomerase, and their regulation in cancer and aging, and highlights small-molecule drugs targeting telomerase in these fields.

引用

页数：12