Sex-specifics of ECT outcome

被引：15

作者：

Blanken, M. A. J. T. ^{[2
,4
]}

Oudega, M. L. ^{[1
,2
,3
,4
]}

Hoogendoorn, A. W. ^{[1
,3
,4
]}

Sonnenberg, C. S. ^{[3
,34
]}

Rhebergen, D. ^{[3
,4
,5
]}

Klumpers, U. M. H. ^{[2
,3
,4
]}

Van Diermen, L. ^{[6
,7
,8
]}

Birkenhager, T. ^{[7
,9
]}

Schrijvers, D. ^{[7
,8
]}

Redlich, R. ^{[10
,11
]}

Dannlowski, U. ^{[11
]}

Heindel, W. ^{[12
]}

Coenjaerts, M. ^{[13
]}

Nordanskog, P. ^{[14
]}

Oltedal, L. ^{[15
,16
]}

Kessler, U. ^{[16
,17
]}

Frid, L. M. ^{[16
]}

Takamiya, A. ^{[18
,19
,22
]}

Kishimoto, T. ^{[18
,19
]}

Jorgensen, M. B. ^{[20
,21
]}

Jorgensen, A. ^{[20
,21
]}

Bolwig, T. ^{[20
,21
]}

Emsell, L. ^{[22
]}

Sienaert, P. ^{[23
]}

Bouckaert, F. ^{[22
]}

Abbott, C. C. ^{[24
]}

Peran, P. ^{[25
]}

Arbus, C. ^{[26
]}

Yrondi, A. ^{[26
]}

Kiebs, M. ^{[27
,28
,36
]}

Philipsen, A. ^{[28
]}

van Waarde, J. A. ^{[29
]}

Prinsen, E. ^{[29
]}

van Verseveld, M. ^{[29
]}

Van Wingen, G. ^{[30
,37
]}

ten Doesschate, F. ^{[29
,30
]}

Camprodon, J. A. ^{[31
]}

Kritzer, M. ^{[31
]}

Barbour, T. ^{[32
]}

Argyelan, M. ^{[38
]}

Cardoner, N. ^{[39
,40
,41
]}

Urretavizcaya, M. ^{[41
,42
,43
]}

Soriano-Mas, C. ^{[41
,42
,44
]}

Narr, K. L. ^{[45
]}

Espinoza, R. T. ^{[45
]}

Prudic, J. ^{[46
]}

Rowny, S. ^{[46
]}

van Eijndhoven, Ph. ^{[33
]}

Tendolkar, I. ^{[33
]}

Dols, A. ^{[2
,4
,35
]}

机构：

[1] GGZ InGeest Specialized Mental Hlth Care, Amsterdam, Netherlands

[2] Vrije Univ, Amsterdam Neurosci, Psychiat, Amsterdam UMC, Amsterdam, Netherlands

[3] Vrije Univ, Amsterdam Publ Hlth Res Inst, Psychiat, Amsterdam UMC, Amsterdam, Netherlands

[4] Vrije Univ Amsterdam Med Ctr, Amsterdam UMC, Amsterdam, Netherlands

[5] GGZ Cent, Specialized Mental Hlth Care, Amersfoort, Netherlands

[6] Psychiat Ctr Bethanie, Andreas Vesaliuslaan 39, B-2980 Zoersel, Belgium

[7] Univ Antwerp, Dept Biomed Sci, Collaborat Antwerp Psychiat Res Inst CAPRI, Fac Med & Hlth Sci, Univ Pl 1, B-2610 Antwerp, Belgium

[8] Univ Psychiat Ctr UPC Duffel, Stn Str 22c, B-2570 Duffel, Belgium

[9] Erasmus MC, Rotterdam, Netherlands

[10] Univ Halle, Dept Psychol, Halle, Germany

[11] Univ Munster, Inst Translat Psychiat, Munster, Germany

[12] Univ Munster, Dept Radiol, Munster, Germany

[13] Univ Hosp Bonn, Dept Psychiat & Psychotherapy, Div Med Psychol, Venusberg Campus 1, D-53127 Bonn, Germany

[14] Linkoping Univ, Dept Biomed & Clin Sci, Dept Psychiat, Ctr Social & Affect Neurosci, Linkoping, Sweden

[15] Haukeland Hosp, Dept Radiol, Mohn Med Imaging & Visualizat Ctr, Bergen, Norway

[16] Univ Bergen, Dept Clin Med, Bergen, Norway

[17] Haukeland Hosp, Div Psychiat, NORMENT, Bergen, Norway

[18] Keio Univ, Dept Neuropsychiat, Sch Med, Tokyo, Japan

[19] Keio Univ, Hills Joint Res Lab Future Prevent Med & Wellness, Sch Med, Tokyo, Japan

[20] Univ Copenhagen, Psychiat Ctr Copenhagen, Copenhagen, Denmark

[21] Univ Copenhagen, Inst Clin Med, Copenhagen, Denmark

[22] Katholieke Univ Leuven, Leuven Brain Inst, Dept Neurosci, Neuropsychiat, Kortenberg, Belgium

[23] Katholieke Univ Leuven, Univ Psychiat Ctr UPC, Acad Ctr ECT & Neuromodulat AcCENT, Kortenberg, Belgium

[24] Univ New Mexico, Dept Psychiat, Albuquerque, NM 87131 USA

[25] Univ Toulouse, INSERM, UPS, Toulouse NeuroImaging Ctr, Toulouse, France

[26] Univ Toulouse, INSERM, UPS,CHU Toulouse,Hosp Purpan,Ctr Expert Depress R, Toulouse NeuroImaging Ctr,Serv Psychiat & Psychol, Toulouse, France

[27] Univ Bonn, Dept Psychiat & Psychotherapy, Bonn, Germany

[28] Univ Bonn, Sect Med Psychol, Bonn, Germany

[29] Rijnstate Arnhem, Arnhem, Netherlands

[30] Univ Amsterdam, Dept Psychiat, Amsterdam UMC, Meibergdreef 9, Amsterdam, Netherlands

[31] Harvard Med Sch, Massachusetts Gen Hosp, Dept Psychiat, Div Neuropsychiat, Boston, MA USA

[32] Massachusetts Gen Hosp, Boston, MA 02114 USA

[33] Radboud Univ Nijmegen, Nijmegen, Netherlands

[34] GGZ Parnassia NH, Specialized Mental Hlth Care, Castricum, Netherlands

[35] Univ Med Ctr Utrecht, UMC Utrecht Brain Ctr, Dept Psychiat, Utrecht, Netherlands

[36] Univ Hosp Oldenburg, Sch Med & Hlth Sci, Karl Jaspers Clin, Oldenburg, Germany

[37] Amsterdam Neurosci, Amsterdam, Netherlands

[38] Feinstein Inst Med Res, Inst Behav Sci, Manhasset, NY USA

[39] Hosp Santa Creu & Sant Pau, St Pau Mental Hlth Res Grp, IIB St Pau, Barcelona, Spain

[40] Univ Autonoma Barcelona, Sch Med Bellaterra, Dept Psychiat & Forens Med, Barcelona, Spain

[41] Carlos III Hlth Inst, CIBERSAM, Madrid, Spain

[42] Bellvitge Univ Hosp, Dept Psychiat, Bellvitge Biomed Res Inst IDIBELL, Barcelona, Spain

[43] Univ Barcelona, Dept Clin Sci, Bellvitge Campus, Barcelona, Spain

[44] Univ Barcelona, Dept Social Psychol & Quantitat Psychol, Bellvitge Campus, Barcelona, Spain

[45] Univ Calif Los Angeles, Dept Neurol Psychiat & Biobehav Sci, Los Angeles, CA USA

[46] Columbia Univ, Irving Med Ctr, New York, NY 10027 USA

来源：

JOURNAL OF AFFECTIVE DISORDERS | 2023年 / 326卷

关键词：

Electroconvulsive therapy; ECT; Sex; Sex-specific; Major depressive disorder; Phenotype; Predictor; ELECTROCONVULSIVE-THERAPY; GENDER-DIFFERENCES; DEPRESSIVE-DISORDERS; RATING-SCALE; WOMEN; MEN;

D O I：

10.1016/j.jad.2022.12.144

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Objective: Electroconvulsive therapy (ECT) is the most effective treatment for patients with severe major depressive disorder (MDD). Given the known sex differences in MDD, improved knowledge may provide more sex-specific recommendations in clinical guidelines and improve outcome. In the present study we examine sex differences in ECT outcome and its predictors. Methods: Clinical data from 20 independent sites participating in the Global ECT-MRI Research Collaboration (GEMRIC) were obtained for analysis, totaling 500 patients with MDD (58.6 % women) with a mean age of 54.8 years. Severity of depression before and after ECT was assessed with validated depression scales. Remission was defined as a HAM-D score of 7 points or below after ECT. Variables associated with remission were selected based on literature (i.e. depression severity at baseline, age, duration of index episode, and presence of psychotic symptoms). Results: Remission rates of ECT were independent of sex, 48.0 % in women and 45.7 % in men (X2(1) = 0.2, p = 0.70). In the logistic regression analyses, a shorter index duration was identified as a sex-specific predictor for ECT outcome in women (X2(1) = 7.05, p = 0.01). The corresponding predictive margins did show overlapping confidence intervals for men and women. Conclusion: The evidence provided by our study suggests that ECT as a biological treatment for MDD is equally effective in women and men. A shorter duration of index episode was an additional sex-specific predictor for remission in women. Future research should establish whether the confidence intervals for the corresponding predictive margins are overlapping, as we find, or not.

引用

页码：243 / 248

页数：6

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