Gastroesophageal reflux disease in children: What's new right now?

被引：11

作者：

Sintusek, Palittiya ^{[1
]}

Mutalib, Mohamed ^{[2
]}

Thapar, Nikhil ^{[3
,4
,5
,6
]}

机构：

[1] Chulalongkorn Univ, Fac Med, King Chulalongkorn Mem Hosp & Thai Red Cross, Div Gastroenterol,Dept Pediat,Thai Pediat Gastroen, Bangkok 10330, Thailand

[2] Evelina London Childrens Hosp, Dept Paediat Gastroenterol Pediat & Gastroenterol, London SE1 7EH, England

[3] Queensland Childrens Hosp, Dept Gastroenterol Hepatol & Liver Transplant, Brisbane, Qld 4101, Australia

[4] Univ Queensland, Sch Med, Brisbane, Qld 4006, Australia

[5] Queensland Univ Technol, Woolworths Ctr Child Nutr Res, Brisbane, Qld 4101, Australia

[6] Queensland Childrens Hosp, Dept Gastroenterol Hepatol & Liver Transplant, 501 Stanley St, Brisbane, Qld 4101, Australia

来源：

WORLD JOURNAL OF GASTROINTESTINAL ENDOSCOPY | 2023年 / 15卷 / 03期

关键词：

Gastroesophageal reflux; Gastroesophageal reflux disease; Children; Infant; Impedance study; Lower esophageal sphincter; PROTON-PUMP INHIBITORS; NEUROLOGICALLY IMPAIRED CHILDREN; LOWER ESOPHAGEAL SPHINCTER; COWS MILK ALLERGY; TRANSORAL INCISIONLESS FUNDOPLICATION; DOUBLE-BLIND; NECROTIZING ENTEROCOLITIS; NISSEN FUNDOPLICATION; BACTERIAL OVERGROWTH; PEDIATRIC-PATIENTS;

D O I：

10.4253/wjge.v15.i3.84

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Gastroesophageal reflux (GER) in children is very common and refers to the involuntary passage of gastric contents into the esophagus. This is often physiological and managed conservatively. In contrast, GER disease (GERD) is a less common pathologic process causing troublesome symptoms, which may need medical management. Apart from abnormal transient relaxations of the lower esophageal sphincter, other factors that play a role in the pathogenesis of GERD include defects in esophageal mucosal defense, impaired esophageal and gastric motility and clearance, as well as anatomical defects of the lower esophageal reflux barrier such as hiatal hernia. The clinical manifestations of GERD in young children are varied and nonspecific prompting the necessity for careful diagnostic evaluation. Management should be targeted to the underlying aetiopathogenesis and to limit complications of GERD. The following review focuses on up-to-date information regarding of the pathogenesis, diagnostic evaluation and management of GERD in children.

引用

页码：84 / 102

页数：19