Plasminogen Activator Inhibitor-1 4G/5G Promoter Polymorphism in Indian Patients with Deep Vein Thrombosis

被引：0

作者：

Sharma, Saniya ^{[1
]}

Jamwal, Manu ^{[1
]}

Uppal, Varun ^{[1
]}

Senee, Hari Kishan ^{[1
]}

Jindal, Manav ^{[1
]}

Ahluwalia, Jasmina ^{[1
]}

Das, Reena ^{[1
]}

Varma, Neelam ^{[1
]}

Malhotra, Pankaj ^{[2
]}

Kumar, Narender ^{[1
]}

机构：

[1] Postgrad Inst Med Educ & Res PGIMER, Dept Hematol, Level 5,Res Block A,Sect 12, Chandigarh 160012, India

[2] Postgrad Inst Med Educ & Res PGIMER, Dept Clin Haematol & Med Oncol, Sect 12, Chandigarh 160012, India

来源：

INDIAN JOURNAL OF HEMATOLOGY AND BLOOD TRANSFUSION | 2024年 / 40卷 / 02期

关键词：

Deep vein thrombosis; Fibrinolysis; Plasminogen activator inhibitor-1; PAI-1; 4G; 5G polymorphism; Thrombophilia; VENOUS THROMBOEMBOLISM; RISK; GENOTYPE;

D O I：

10.1007/s12288-023-01660-3

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A single guanosine deletion/insertion (4G/5G) polymorphism in the promoter region of plasminogen activator inhibitor-1 (PAI-1) gene encoding PAI-1 protein has been investigated in deep vein thrombosis (DVT) patients. The association between PAI-1 4G/5G polymorphism and increased risk of DVT has been reported in some studies, while others have reported a lack of association. The present study aimed to investigate if the PAI-1 4G/5G polymorphism is associated with an increased risk of DVT in the Indian population and to assess its association with thrombophilic risk factors. Fifty-two adult patients with a history of chronic or recurrent DVT and 52 healthy adult controls were genotyped for PAI-1 4G/5G polymorphism. Plasma levels of PAI-1 and other thrombophilic risk factors were also measured. PAI-1 4G/5G polymorphism was not significantly associated with an increased risk of DVT. Protein C deficiency was significantly associated with the 4G/4G genotype. Patients with the 4G/4G genotype had significantly reduced PAI-1 levels as compared to the controls. PAI-1 4G/5G polymorphism did not significantly contribute to an increased risk of DVT in the Indian population. However, in the presence of thrombophilic risk factor abnormalities, the risk of DVT is increased in individuals with the 4G/4G genotype in the Indian cohort.

引用

页码：331 / 334

页数：4

共 14 条

[1] Effect of plasminogen activator inhibitor-1 4G/5G polymorphism in Turkish deep vein thrombotic patients with and without FV1691 G-A [J].