Case report: Acute pancreatitis in lung adenocarcinoma with small cell transformation after multiple line targeted therapy

被引:0
作者
Jing, Yaoyao [1 ]
Li, Xiaoxiao [2 ]
Sun, Xiaoyuan [2 ]
Ren, Minghan [1 ]
Xiao, Ruoxi [1 ]
Zhao, Jiayu [1 ]
Liu, Zimin [1 ,2 ]
机构
[1] Qingdao Univ, Dept Med, Qingdao, Peoples R China
[2] Qingdao Univ, Dept Digest Oncol, Affiliated Hosp, Qingdao, Peoples R China
关键词
pancreatic metastasis; lung adenocarcinoma; small cell lung cancer transformation; metastasis-induced acute pancreatitis; case report; GASTRIN-RELEASING PEPTIDE; SECONDARY TUMORS; CANCER; METASTASIS; MARKER; NEUROENDOCRINE; DIAGNOSIS; ASSAY;
D O I
10.3389/fonc.2024.1274034
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
In lung cancer, metastasis to the liver, bones, brain, and adrenal glands is more commonly observed, whereas pancreatic metastasis from lung cancer is relatively rare. We present a case of a patient with an 8-year history of lung adenocarcinoma (LUAD) who was admitted to our institution exhibiting symptoms consistent with acute pancreatitis. Subsequent histopathological examination through puncture confirmed the occurrence of pancreatic metastasis originating from small cell lung cancer (SCLC). During a multidisciplinary team discussion, we reached a consensus in diagnosing the patient with post-transformation small cell carcinoma alongside moderately severe pancreatitis, which was determined to be a consequence of pancreatic metastasis. The patient received a regimen of etoposide and cisplatin chemotherapy. This unique clinical case highlights the importance of further investigating the factors contributing to pancreatic metastasis in patients with lung cancer, as the underlying mechanisms remain unclear. Understanding these exceptional metastatic events is vital in devising effective therapeutic strategies and improving patient prognosis. Our findings emphasize the need for continued surveillance and comprehensive management of lung cancer patients, particularly those with resistant forms of the disease, to promptly identify and address the progression of metastatic events to uncommon sites such as the pancreas.
引用
收藏
页数:7
相关论文
共 34 条
[1]   Secondary tumors of the pancreas: an analysis of a surgical and autopsy database and review of the literature [J].
Adsay, NV ;
Andea, A ;
Basturk, O ;
Kilinc, N ;
Nassar, H ;
Cheng, JD .
VIRCHOWS ARCHIV, 2004, 444 (06) :527-535
[2]   Early Application of Next-Generation Sequencing Identifies Pancreatic Mass as Metastasis From an EGFR-Mutated Lung Adenocarcinoma [J].
Chen, Luxi ;
Davelaar, John ;
Gaddam, Srinivas ;
Kosari, Kambiz ;
Nissen, Nicholas ;
Chaux, George ;
Lee, Christopher ;
Vail, Eric ;
Hendifar, Andrew ;
Gong, Jun ;
Reckamp, Karen ;
Osipov, Arsen .
JOURNAL OF THE NATIONAL COMPREHENSIVE CANCER NETWORK, 2023, 21 (01) :6-11
[3]   Neuroendocrine transformation from EGFR/ALK-wild type or TKI-naive non-small cell lung cancer: An under-recognized phenomenon [J].
Chu, Xiao ;
Xu, Yuyin ;
Li, Ye ;
Zhou, Yue ;
Chu, Li ;
Yang, Xi ;
Ni, Jianjiao ;
Li, Yida ;
Guo, Tiantian ;
Zheng, Zhiqin ;
Zheng, Qiang ;
Yao, Qianlan ;
Li, Yuan ;
Zhou, Xiaoyan ;
Zhu, Zhengfei .
LUNG CANCER, 2022, 169 :22-30
[4]   Third-generation EGFR and ALK inhibitors: mechanisms of resistance and management [J].
Cooper, Alissa J. ;
Sequist, Lecia, V ;
Lin, Jessica J. .
NATURE REVIEWS CLINICAL ONCOLOGY, 2022, 19 (08) :499-514
[5]  
Duan Jianchun, 2017, Zhongguo Fei Ai Za Zhi, V20, P511, DOI 10.3779/j.issn.1009-3419.2017.08.02
[6]   Therapeutic strategies for EGFR-mutated non-small cell lung cancer patients with osimertinib resistance [J].
Fu, Kai ;
Xie, Fachao ;
Wang, Fang ;
Fu, Liwu .
JOURNAL OF HEMATOLOGY & ONCOLOGY, 2022, 15 (01)
[7]   Analysis of Prognostic Factors in Pancreatic Metastases: A Multicenter Retrospective Analysis [J].
Ito, Takashi ;
Takada, Ryoji ;
Omoto, Shunsuke ;
Tsuda, Motoyuki ;
Masuda, Daisuke ;
Kato, Hironari ;
Matsumoto, Toshihiko ;
Moriyama, Ichiro ;
Okabe, Yoshinobu ;
Shiomi, Hideyuki ;
Ishida, Etsuji ;
Hatamaru, Keiichi ;
Hashimoto, Shinichi ;
Tanaka, Kiyohito ;
Kawamoto, Hirofumi ;
Yanagisawa, Akio ;
Katayama, Toshiro ;
Yazumi, Shujiro .
PANCREAS, 2018, 47 (08) :1033-1039
[8]  
Jeong In Beom, 2006, Korean Journal of Internal Medicine, V21, P132
[9]   EXTRAHEPATIC BILIARY OBSTRUCTION CAUSED BY SMALL-CELL LUNG-CANCER [J].
JOHNSON, DH ;
HAINSWORTH, JD ;
GRECO, FA .
ANNALS OF INTERNAL MEDICINE, 1985, 102 (04) :487-490
[10]   Obstructive pancreatitis secondary to a pancreatic metastasis from lung cancer treated with nasopancreatic drainage [J].
Kawaguchi, Shinya ;
Ohtsu, Takuya ;
Terada, Shuzo ;
Endo, Shinya .
CLINICAL JOURNAL OF GASTROENTEROLOGY, 2019, 12 (04) :382-386